ArticleThe Journal of physiology2007
Properties of spontaneous Ca2+ transients recorded from interstitial cells of Cajal-like cells of the rabbit urethra in situ.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Cells and ionic conductances contributing to spontaneous activity in bladder and urethral smooth muscle.The Journal of physiology · 2026Review
- Orai storeoperated CaChannels (Austin, Tex.) · 2025Review
- Ca²⁺ signaling in myenteric interstitial cells of Cajal (ICC-MY) and their role as conditional pacemakers in the colon.Cell calcium · 2025Article
- What do we really know about the external urethral sphincter?Continence (Amsterdam, Netherlands) · 2024Review
- CaCell calcium · 2021Article
- The intracellular CaProceedings of the National Academy of Sciences of the United States of America · 2020Article
- CaThe Journal of physiology · 2018Article
- Spontaneous Ca(2+) transients in interstitial cells of Cajal located within the deep muscular plexus of the murine small intestine.The Journal of physiology · 2016Article
- Calcium signalling in Cajal-like interstitial cells of the lower urinary tract.Nature reviews. Urology · 2014Review
- Interstitial cells: regulators of smooth muscle function.Physiological reviews · 2014Review
- T-type Ca2+ channels and the urinary and male genital tracts.Pflugers Archiv : European journal of physiology · 2014Review
- Functional and morphological properties of pericytes in suburothelial venules of the mouse bladder.British journal of pharmacology · 2012Article
- Relationship between interstitial cells of Cajal, fibroblast-like cells and inhibitory motor nerves in the internal anal sphincter.Cell and tissue research · 2011Article
- Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra.British journal of pharmacology · 2010Article
- Functions of ICC-like cells in the urinary tract and male genital organs.Journal of cellular and molecular medicine · 2010Review
- Smooth muscle cell calcium activation mechanisms.The Journal of physiology · 2008Review
- Effects of imatinib mesylate on spontaneous electrical and mechanical activity in smooth muscle of the guinea-pig stomach.British journal of pharmacology · 2008Article
- Role of Ca2+ entry and Ca2+ stores in atypical smooth muscle cell autorhythmicity in the mouse renal pelvis.British journal of pharmacology · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interstitial cells of Cajal-like cells (ICC-LCs) in the urethra may act as electrical pacemakers of spontaneous contractions. However, their properties in situ and their interaction with neighbouring urethral smooth muscle cells (USMCs) remain to be elucidated. To further explore the physiological role of ICC-LCs, spontaneous changes in [Ca(2+)](i) (Ca(2+) transients) were visualized in fluo-4 loaded preparations of rabbit urethral smooth muscle. ICC-LCs were sparsely distributed, rather than forming an extensive network. Ca(2+) transients in ICC-LCs had a lower frequency and a longer half-width than those of USMCs. ICC-LCs often exhibited Ca(2+) transients synchronously with each other, but did not often show a close temporal relationship with Ca(2+) transients in USMCs. Nicardipine (1 microm) suppressed Ca(2+) transients in USMCs but not in ICC-LCs. Ca(2+) transients in ICC-LCs were abolished by cyclopiazonic acid (10 microm), ryanodine (50 microm) and caffeine (10 mm) or by removing extracellular Ca(2+), and inhibited by 2-aminoethoxydiphenyl borate (50 microm) and 3-morpholino-sydnonimine (SIN-1; 10 microm), but facilitated by increasing extracellular Ca(2+) or phenylephrine (1-10 microm). These results indicated that Ca(2+) transients in urethral ICC-LCs in situ rely on both Ca(2+) release from intracellular Ca(2+) stores and Ca(2+) influx through non-L-type Ca(2+) channel pathways. ICC-LCs may not act as a coordinated pacemaker electrical network as do ICC in the gastrointestinal (GI) tract. Rather they may randomly increase excitability of USMCs to maintain the tone of urethral smooth muscles.
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