ArticleThe Journal of physiology2007
Roles of phospholipase Cbeta and NMDA receptor in activity-dependent endocannabinoid release.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Electrophysiology of Endocannabinoid Signaling.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Receptor-Dependent and Independent Regulation of Voltage-Gated CaInternational journal of molecular sciences · 2021Review
- Article
- Article
- Hippocampal GABAergic Inhibitory Interneurons.Physiological reviews · 2017Review
- Endocannabinoid control of glutamate NMDA receptors: the therapeutic potential and consequences of dysfunction.Oncotarget · 2016Review
- Marijuana Compounds: A Nonconventional Approach to Parkinson's Disease Therapy.Parkinson's disease · 2016Review
- The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.Oncotarget · 2015Article
- Cannabinoid-mediated short-term plasticity in hippocampus.Journal of computational neuroscience · 2014Article
- A biophysical model of endocannabinoid-mediated short term depression in hippocampal inhibition.PloS one · 2013Article
- DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses.Nature chemical biology · 2012Article
- Assay and inhibition of diacylglycerol lipase activity.Bioorganic & medicinal chemistry letters · 2012Article
- A biophysically-based neuromorphic model of spike rate- and timing-dependent plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Cholinergic modulation of synaptic integration and dendritic excitability in the striatum.Current opinion in neurobiology · 2011Review
- Enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: a neuroprotective therapeutic modality.Life sciences · 2010Review
- Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling.Bioorganic & medicinal chemistry letters · 2008Article
- Enzymatic pathways that regulate endocannabinoid signaling in the nervous system.Chemical reviews · 2008Review
- Compartmentalized signalling in neurons.The Journal of physiology · 2007Article
- Molecular mechanisms underlying neuronal synaptic plasticity: systems biology meets computational neuroscience in the wilds of synaptic plasticity.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endocannabinoids are released from postsynaptic neurons, activate presynaptic cannabinoid receptors and cause various forms of short-term and long-term synaptic plasticity throughout the brain. Using hippocampal and cerebellar neurons, we have revealed that endocannabinoid release can be induced through two different pathways. One is independent of phospholipase Cbeta (PLCbeta) and driven by Ca(2+) elevation alone (Ca(2+)-driven endocannabinoid release, CaER), and the other is PLCbeta-dependent and driven by activation of G(q/11)-coupled receptors (receptor-driven endocannabinoid release, RER). CaER is induced by activation of either voltage-gated Ca(2+) channels or NMDA receptors. RER is functional even at resting Ca(2+) levels (basal RER), but markedly enhanced by a small Ca(2+) elevation (Ca(2+)-assisted RER). In Ca(2+)-assisted RER, PLCbeta serves as a coincidence detector of receptor activation and Ca(2+) elevation. We have also demonstrated that Ca(2+)-assisted RER is essential for the endocannabinoid release triggered by synaptic activity. Our anatomical data show that a set of receptors and enzymes required for RER are well organized so that the excitatory input can trigger RER effectively. Certain forms of spike-timing-dependent plasticity (STDP) are reported to depend on endocannabinoid signalling. The NMDA receptor and PLCbeta might play key roles in the endocannabinoid-dependent forms of STDP as coincidence detectors with different timing dependences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.