ReviewNeuroscience and biobehavioral reviews2007
Convergent Functional Genomics of bipolar disorder: from animal model pharmacogenomics to human genetics and biomarkers.
Review in Neuroscience and biobehavioral reviews, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Gene Encoding Protocadherin 9 (PCDH9), a Novel Risk Factor for Major Depressive Disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Pooled it
- Identification of a Bipolar Disorder Vulnerable Gene CHDH at 3p21.1.Molecular neurobiology · 2017Article
- Neuro-psychopharmacological perspective of Orphan receptors of Rhodopsin (class A) family of G protein-coupled receptors.Psychopharmacology · 2017Review
- Stress-Related Immune Markers in Depression: Implications for Treatment.The international journal of neuropsychopharmacology · 2016Review
- Omics-Based Biomarkers: Application of Metabolomics in Neuropsychiatric Disorders.The international journal of neuropsychopharmacology · 2015Review
- Article
- Discovery and validation of blood biomarkers for suicidality.Molecular psychiatry · 2013Article
- Convergent functional genomics of stem cell-derived cells.Translational psychiatry · 2013Article
- Chemocentric informatics approach to drug discovery: identification and experimental validation of selective estrogen receptor modulators as ligands of 5-hydroxytryptamine-6 receptors and as potential cognition enhancers.Journal of medicinal chemistry · 2012Article
- Expression profiling in neuropsychiatric disorders: emphasis on glutamate receptors in bipolar disorder.Pharmacology, biochemistry, and behavior · 2012Review
- Article
- Using genome-wide expression profiling to define gene networks relevant to the study of complex traits: from RNA integrity to network topology.International review of neurobiology · 2012Review
- Convergent functional genomics of anxiety disorders: translational identification of genes, biomarkers, pathways and mechanisms.Translational psychiatry · 2011Article
- Identification of blood biomarkers for psychosis using convergent functional genomics.Molecular psychiatry · 2011Article
- Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment.Annals of the New York Academy of Sciences · 2010Review
- Biomarkers in psychiatry: drawbacks and potential for misuse.International archives of medicine · 2010Article
- Ontological Discovery Environment: a system for integrating gene-phenotype associations.Genomics · 2009Article
- Article
- A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2009Article
- An E3 ubiquitin ligase, Really Interesting New Gene (RING) Finger 41, is a candidate gene for anxiety-like behavior and beta-carboline-induced seizures.Biological psychiatry · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Progress in understanding the genetic and neurobiological basis of bipolar disorder(s) has come from both human studies and animal model studies. Until recently, the lack of concerted integration between the two approaches has been hindering the pace of discovery, or more exactly, constituted a missed opportunity to accelerate our understanding of this complex and heterogeneous group of disorders. Our group has helped overcome this "lost in translation" barrier by developing an approach called convergent functional genomics (CFG). The approach integrates animal model gene expression data with human genetic linkage/association data, as well as human tissue (postmortem brain, blood) data. This Bayesian strategy for cross-validating findings extracts meaning from large datasets, and prioritizes candidate genes, pathways and mechanisms for subsequent targeted, hypothesis-driven research. The CFG approach may also be particularly useful for identification of blood biomarkers of the illness.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.