Evidence map›Paper›PMID 17613280›Full record

Trial reportClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2007

A prospective, randomized trial of clear liquids versus low-fat solid diet as the initial meal in mild acute pancreatitis.

Brian C Jacobson, Martha B Vander Vliet, Michael D Hughes, Rie Maurer, Katherine McManus, Peter A Banks

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 37 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 8 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03829085 nacompletednot on this mapstarted 2017, after this paper: background citation

Randomized Multicenter Prospective Clinical Trial to Compare the Effectiveness of Starting Early Oral Diet Versus Nil Per Oral in Patients With Acute Pancreatitis

TypeinterventionalSponsorConsorci Sanitari del GarrafRan2017 to 2018Enrolled120ConditionsPancreatitis, AcuteArmsEARLY ORAL REFEEDING
NCT04932785 naunknown statusnot on this mapstarted 2021, after this paper: background citation

To Assess the Comparative Efficacy of Full Calorie Regular Diet (RD) Versus Clear Liquid Diet (CLD) on Length of Hospital Stay (LOHS) for Mild to Moderate Acute Pancreatitis (AP)

TypeinterventionalSponsorUniversity of Southern CaliforniaRan2021 to 2024Enrolled150ConditionsPancreatitis, Diet, Food, and Nutrition, Diet, Pancreatic DiseaseArmsRegular diet, Clear Liquid Diet
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 8 syntheses or guidelines pooled it, 150 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Guideline
  4. Guideline
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. A meta-analysis of early oral refeeding and quickly increased diet for patients with mild acute pancreatitis.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
    Pooled it
  9. Nutrition in Pancreatic Diseases: A Roadmap for the Gastroenterologist.GE Portuguese journal of gastroenterology · 2024
    Review
  10. Article
  11. Review
  12. Review
  13. Diagnosis and Treatment of Acute Pancreatitis.Diagnostics (Basel, Switzerland) · 2022
    Review
  14. Article
  15. Review
  16. Management of acute pancreatitis in the first 72 hours.Current opinion in gastroenterology · 2018
    Review
  17. ERCP or NO ERCP: the case report of a frail patient.Internal and emergency medicine · 2018
    Article
  18. Non-liquid as initial meal in mild acute pancreatitis: Renewed meta-analysis.JGH open : an open access journal of gastroenterology and hepatology · 2018
    Article
  19. Review
  20. Mechanisms and Management of Acute Pancreatitis.Gastroenterology research and practice · 2018
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Brian C JacobsonSection of Gastroenterology, Boston University Medical Center, 85 East Concord Street, Room 7721, Boston, Massachusetts 02118, USA. brian.jacobson@bmc.org
Martha B Vander Vliet
Michael D Hughes
Rie Maurer
Katherine McManus
Peter A Banks
Boston University · USBrigham and Women's Hospital · US

Funding

Risk Factors for Barrett's EsophagusK08DK070706 · NIDDK · BOSTON MEDICAL CENTER · PI JACOBSON, BRIAN C · 2005 to 2009
$642k
NIDDK NIH HHS K08 DK070706
6 · The paper itself

Abstract

BACKGROUND &

aimsPatients recovering from mild acute pancreatitis typically receive a clear liquid diet (CLD) when ready to initiate oral nutrition. Patient discharge then depends on their successful advancement to solid food. We hypothesized that initiating oral nutrition with a low-fat solid diet (LFSD) after mild pancreatitis would be well tolerated and would result in a shorter length of hospitalization (LOH).

methodsPatients with mild pancreatitis were randomized to a CLD or LFSD when they were ready to resume oral nutrition. Decisions about diet advancement and hospital discharge were at the discretion of the medical team, without input from study team members. Patients were monitored daily for recurrence of pain, need to stop feeding, post-refeeding LOH (primary end point), and for 28 days post-refeeding to capture re-admission rates.

resultsWe randomized 121 patients: 66 to CLD and 55 to LFSD. The number of patients requiring cessation of feeding because of pain or nausea was similar in both groups (6% for CLD, 11% for LFSD; P = .51). The median LOH after refeeding was identical in both groups (1-day interquartile range, 1-2; P = .77). Patients in the LFSD arm consumed significantly more calories and grams of fat than those in the CLD arm during their first meal and on study day 1. There was no difference in the 28-day re-admission rates between the 2 arms.

conclusionsInitiating oral nutrition after mild acute pancreatitis with an LFSD appeared safe and provided more calories than a CLD, but did not result in a shorter LOH.

Indexed as

Cholangiopancreatography, Endoscopic RetrogradeDietary FatsDiet, Fat-RestrictedFemaleFollow-Up StudiesHumansLength of StayMaleMiddle AgedNutritional SupportPancreatitis, Acute NecrotizingProspective StudiesSeverity of Illness IndexTomography, X-Ray ComputedTreatment OutcomeDietary Fats

Identifiers

PMID17613280
PMCPMC2034288
OpenAlexW2028844827

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.