ArticleJournal of molecular biology2007
Structural metals in the group I intron: a ribozyme with a multiple metal ion core.
Article in Journal of molecular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Molecular insights into de novo small-molecule recognition by an intron RNA structure.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Why Nature Chose Potassium.Journal of molecular evolution · 2019Review
- Nucleobase carbonyl groups are poor MgRNA (New York, N.Y.) · 2019Article
- Structural Divergence of the Group I Intron Binding Surface in Fungal Mitochondrial Tyrosyl-tRNA Synthetases That Function in RNA Splicing.The Journal of biological chemistry · 2016Article
- A DNAzyme requiring two different metal ions at two distinct sites.Nucleic acids research · 2016Article
- How do metal ions direct ribozyme folding?Nature chemistry · 2015Article
- A new heavy lanthanide-dependent DNAzyme displaying strong metal cooperativity and unrescuable phosphorothioate effect.Nucleic acids research · 2015Article
- A G-quadruplex-containing RNA activates fluorescence in a GFP-like fluorophore.Nature chemical biology · 2014Article
- Nucleic acid catalysis: metals, nucleobases, and other cofactors.Chemical reviews · 2014Review
- Principles of ion recognition in RNA: insights from the group II intron structures.RNA (New York, N.Y.) · 2014Article
- Solving nucleic acid structures by molecular replacement: examples from group II intron studies.Acta crystallographica. Section D, Biological crystallography · 2013Review
- Now on display: a gallery of group II intron structures at different stages of catalysis.Mobile DNA · 2013Article
- Exploring purine N7 interactions via atomic mutagenesis: the group I ribozyme as a case study.RNA (New York, N.Y.) · 2012Article
- Testing the nearest neighbor model for canonical RNA base pairs: revision of GU parameters.Biochemistry · 2012Article
- RNA molecules with conserved catalytic cores but variable peripheries fold along unique energetically optimized pathways.RNA (New York, N.Y.) · 2011Article
- Insights into metalloregulation by M-box riboswitch RNAs via structural analysis of manganese-bound complexes.Journal of molecular biology · 2011Article
- Hammerhead ribozymes: true metal or nucleobase catalysis? Where is the catalytic power from?Molecules (Basel, Switzerland) · 2010Article
- The tertiary structure of group II introns: implications for biological function and evolution.Critical reviews in biochemistry and molecular biology · 2010Review
- A rearrangement of the guanosine-binding site establishes an extended network of functional interactions in the Tetrahymena group I ribozyme active site.Biochemistry · 2010Article
- The identity of the nucleophile substitution may influence metal interactions with the cleavage site of the minimal hammerhead ribozyme.Biochemistry · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Metal ions play key roles in the folding and function for many structured RNAs, including group I introns. We determined the X-ray crystal structure of the Azoarcus bacterial group I intron in complex with its 5' and 3' exons. In addition to 222 nucleotides of RNA, the model includes 18 Mg(2+) and K(+) ions. Five of the metals bind within 12 A of the scissile phosphate and coordinate the majority of the oxygen atoms biochemically implicated in conserved metal-RNA interactions. The metals are buried deep within the structure and form a multiple metal ion core that is critical to group I intron structure and function. Eight metal ions bind in other conserved regions of the intron structure, and the remaining five interact with peripheral structural elements. Each of the 18 metals mediates tertiary interactions, facilitates local bends in the sugar-phosphate backbone or binds in the major groove of helices. The group I intron has a rich history of biochemical efforts aimed to identify RNA-metal ion interactions. The structural data are correlated to the biochemical results to further understand the role of metal ions in group I intron structure and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.