ArticleMalaria journal2007
A major genetic locus controlling natural Plasmodium falciparum infection is shared by East and West African Anopheles gambiae.
Article in Malaria journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 25 citations in OpenAlex.
- Functional characterization of transcriptional enhancers in an Anopheles genetic locus controlling natural resistance to the malaria parasite, Plasmodium falciparum.Epigenetics & chromatin · 2025Article
- Genetics and immunity of Anopheles response to the entomopathogenic fungus Metarhizium anisopliae overlap with immunity to Plasmodium.Scientific reports · 2022Article
- Gene Drive for Mosquito Control: Where Did It Come from and Where Are We Headed?International journal of environmental research and public health · 2017Review
- Association mapping by pooled sequencing identifies TOLL 11 as a protective factor against Plasmodium falciparum in Anopheles gambiae.BMC genomics · 2015Article
- The kdr-bearing haplotype and susceptibility to Plasmodium falciparum in Anopheles gambiae: genetic correlation and functional testing.Malaria journal · 2015Article
- An overview of malaria transmission from the perspective of Amazon Anopheles vectors.Memorias do Instituto Oswaldo Cruz · 2015Review
- Interactions between a fungal entomopathogen and malaria parasites within a mosquito vector.Malaria journal · 2015Article
- Article
- The Anopheles innate immune system in the defense against malaria infection.Journal of innate immunity · 2014Review
- Evidence for population-specific positive selection on immune genes of Anopheles gambiae.G3 (Bethesda, Md.) · 2012Article
- Anopheles gambiae pathogen susceptibility: the intersection of genetics, immunity and ecology.Current opinion in microbiology · 2012Review
- Article
- Exceptional diversity, maintenance of polymorphism, and recent directional selection on the APL1 malaria resistance genes of Anopheles gambiae.PLoS biology · 2011Article
- Polymorphisms in Anopheles gambiae immune genes associated with natural resistance to Plasmodium falciparum.PLoS pathogens · 2010Article
- Uncertainty in mapping malaria epidemiology: implications for control.Epidemiologic reviews · 2010Article
- Fine pathogen discrimination within the APL1 gene family protects Anopheles gambiae against human and rodent malaria species.PLoS pathogens · 2009Article
- Inferring selection in the Anopheles gambiae species complex: an example from immune-related serine protease inhibitors.Malaria journal · 2009Article
- Comparison of male reproductive success in malaria-refractory and susceptible strains of Anopheles gambiae.Malaria journal · 2008Article
- Ecological immunology of mosquito-malaria interactions.Trends in parasitology · 2008Review
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenetic linkage mapping identified a region of chromosome 2L in the Anopheles gambiae genome that exerts major control over natural infection by Plasmodium falciparum. This 2L Plasmodium-resistance interval was mapped in mosquitoes from a natural population in Mali, West Africa, and controls the numbers of P. falciparum oocysts that develop on the vector midgut. An important question is whether genetic variation with respect to Plasmodium-resistance exists across Africa, and if so whether the same or multiple geographically distinct resistance mechanisms are responsible for the trait.
methodsTo identify P falciparum resistance loci in pedigrees generated and infected in Kenya, East Africa, 28 microsatellite loci were typed across the mosquito genome. Genetic linkage mapping was used to detect significant linkage between genotype and numbers of midgut oocysts surviving to 7-8 days post-infection.
resultsA major malaria-control locus was identified on chromosome 2L in East African mosquitoes, in the same apparent position originally identified from the West African population. Presence of this resistance locus explains 75% of parasite free mosquitoes. The Kenyan resistance locus is named EA_Pfin1 (East Africa_ Plasmodium falciparum Infection Intensity).
conclusionDetection of a malaria-control locus at the same chromosomal location in both East and West African mosquitoes indicates that, to the level of genetic resolution of the analysis, the same mechanism of Plasmodium-resistance, or a mechanism controlled by the same genomic region, is found across Africa, and thus probably operates in A. gambiae throughout its entire range.
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