ArticleThe EMBO journal2007
Gene cluster lock after pheromone receptor gene choice.
Article in The EMBO journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Chemosensory Receptors in Vertebrates: Structure and Computational Modeling Insights.International journal of molecular sciences · 2025Review
- Article
- Molecular, Cellular, and Developmental Organization of the Mouse Vomeronasal organ at Single Cell Resolution.bioRxiv : the preprint server for biology · 2024Article
- Epigenetic programming of stochastic olfactory receptor choice.Genesis (New York, N.Y. : 2000) · 2024Review
- Clustering of vomeronasal receptor genes is required for transcriptional stability but not for choice.Science advances · 2022Article
- A purely bioinformatic pipeline for the prediction of mammalian odorant receptor gene enhancers.BMC bioinformatics · 2019Article
- Sense of Smell: Structural, Functional, Mechanistic Advancements and Challenges in Human Olfactory Research.Current neuropharmacology · 2019Article
- Signal Detection and Coding in the Accessory Olfactory System.Chemical senses · 2018Review
- Rescue of an aggressive female sexual courtship in mice by CRISPR/Cas9 secondary mutation in vivo.BMC research notes · 2018Article
- Olfactory receptor accessory proteins play crucial roles in receptor function and gene choice.eLife · 2017Article
- Regulatory Features for Odorant Receptor Genes in the Mouse Genome.Frontiers in genetics · 2017Review
- Elevated Cytosolic Cl- Concentrations in Dendritic Knobs of Mouse Vomeronasal Sensory Neurons.Chemical senses · 2016Article
- Trace amine-associated receptors: ligands, neural circuits, and behaviors.Current opinion in neurobiology · 2015Review
- Chemosensory receptor specificity and regulation.Annual review of neuroscience · 2015Review
- Strong links between genomic and anatomical diversity in both mammalian olfactory chemosensory systems.Proceedings. Biological sciences · 2014Article
- Functional promiscuity in a mammalian chemosensory system: extensive expression of vomeronasal receptors in the main olfactory epithelium of mouse lemurs.Frontiers in neuroanatomy · 2014Article
- An olfactory subsystem that mediates high-sensitivity detection of volatile amines.Cell reports · 2012Article
- Organization of vomeronasal sensory coding revealed by fast volumetric calcium imaging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Allele-biased expression in differentiating human neurons: implications for neuropsychiatric disorders.PloS one · 2012Article
- Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammals, perception of pheromones is based on the expression in each vomeronasal sensory neuron of a limited set of receptor genes, chosen among a large repertoire. Here, we report an extremely tight control of the monogenic and monoallelic transcription of the V1rb2 receptor gene. Combining genetic and electrophysiological approaches, we show that the transcription of a non-functional V1r allele leads to the coexpression of another, functional V1r gene. The choice of this coexpressed gene surprisingly includes genes located on the cluster homologous to the one from which the mutant allele is transcribed. However, V1r genes located in cis relative to the transcribed mutant allele are excluded from the coexpression choice. Our observations strongly suggest a monogenic regulatory mechanism acting (a) at a general level, via the expression of the V1r receptor itself, and (b) at a more local level, defined by the V1r gene cluster.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.