Evidence map›Paper›PMID 17611589›Full record

ArticleGenes and immunity2007

DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West Africans.

R Olesen, C Wejse, D R Velez, C Bisseye, M Sodemann, P Aaby, P Rabna, A Worwui, H Chapman, M Diatta and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Genes and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 11 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 11 syntheses or guidelines pooled it, 185 citations in OpenAlex.

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  5. Association of polymorphisms in Toll-like receptors 4 and 9 with risk of pulmonary tuberculosis: a meta-analysis.Medical science monitor : international medical journal of experimental and clinical research · 2015
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 4 countries.

R OlesenMRC Laboratories, Banjul, The Gambia.
C Wejse
D R Velez
C Bisseye
M Sodemann
P Aaby
P Rabna
A Worwui
H Chapman
M Diatta
R A Adegbola
P C Hill
L Østergaard
S M Williams
G Sirugo
MRC Unit the Gambia · GMAarhus University Hospital · DKStatens Serum Institut · DKVanderbilt University · US

Funding

Training Program on Genetic Variation and Human PhenotypesT32GM080178 · NIGMS · VANDERBILT UNIVERSITY · PI COX, NANCY J, SAMUELS, DAVID C · 2007 to 2021
$3.1M
Medical Research Council MC_U190071468NIGMS NIH HHS T32 GM080178
6 · The paper itself

Abstract

We investigated the role of DC-SIGN (CD209), long pentraxin 3 (PTX3) and vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) in susceptibility to pulmonary tuberculosis (TB) in 321 TB cases and 347 healthy controls from Guinea-Bissau. Five additional, functionally relevant SNPs within toll-like receptors (TLRs) 2, 4 and 9 were typed but found, when polymorphic, not to affect host vulnerability to pulmonary TB. We did not replicate an association between SNPs in the DC-SIGN promoter and TB. However, we found that two polymorphisms, one in DC-SIGN and one in VDR, were associated in a nonadditive model with disease risk when analyzed in combination with ethnicity (P=0.03 for DC-SIGN and P=0.003 for VDR). In addition, PTX3 haplotype frequencies significantly differed in cases compared to controls and a protective effect was found in association with a specific haplotype (OR 0.78, 95% CI 0.63-0.98). Our findings support previous data showing that VDR SNPs modulate the risk for TB in West Africans and suggest that variation within DC-SIGN and PTX3 also affect the disease outcome.

Indexed as

Polymorphism, Single NucleotideAdolescentAdultCase-Control StudiesCell Adhesion MoleculesC-Reactive ProteinDC-Specific ICAM-3 Grabbing NonintegrinFemaleGenetic Predisposition to DiseaseGenotypeGuinea-BissauHaplotypesHumansLectins, C-TypeMaleMycobacterium tuberculosisCell Adhesion MoleculesC-Reactive ProteinDC-Specific ICAM-3 Grabbing NonintegrinLectins, C-TypePentraxinsReceptors, CalcitriolReceptors, Cell SurfaceSerum Amyloid P-ComponentToll-Like Receptors

Identifiers

PMID17611589
OpenAlexW2075464412

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.