ArticleGene therapy2007
Aerosol-delivered programmed cell death 4 enhanced apoptosis, controlled cell cycle and suppressed AP-1 activity in the lungs of AP-1 luciferase reporter mice.
Article in Gene therapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- MiR-21 and let-7 cooperation in the regulation of lung cancer.Frontiers in oncology · 2022Article
- The Role and Interactions of Programmed Cell Death 4 and its Regulation by microRNA in Transformed Cells of the Gastrointestinal Tract.Frontiers in oncology · 2022Review
- Administration of mircoRNA-135b-reinforced exosomes derived from MSCs ameliorates glucocorticoid-induced osteonecrosis of femoral head (ONFH) in rats.Journal of cellular and molecular medicine · 2020Article
- Control Mechanisms of the Tumor Suppressor PDCD4: Expression and Functions.International journal of molecular sciences · 2019Review
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- Estrogen receptor alpha promotes smoking-carcinogen-induced lung carcinogenesis via cytochrome P450 1B1.Journal of molecular medicine (Berlin, Germany) · 2015Article
- Therapeutic efficiency of folated poly(ethylene glycol)-chitosan-graft-polyethylenimine-Pdcd4 complexes in H-ras12V mice with liver cancer.International journal of nanomedicine · 2013Article
- Vectors for inhaled gene therapy in lung cancer. Application for nano oncology and safety of bio nanotechnology.International journal of molecular sciences · 2012Review
- Tumour suppressive function and modulation of programmed cell death 4 (PDCD4) in ovarian cancer.PloS one · 2012Article
- Aerosol delivery of kinase-deficient Akt1 attenuates Clara cell injury induced by naphthalene in the lungs of dual luciferase mice.Journal of veterinary science · 2011Article
- AKT Activation by Pdcd4 Knockdown Up-Regulates Cyclin D1 Expression and Promotes Cell Proliferation.Genes & cancer · 2011Article
- The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic beta cell death.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Decreased level of PDCD4 (programmed cell death 4) protein activated cell proliferation in the lung of A/J mouse.Journal of aerosol medicine and pulmonary drug delivery · 2010Article
- Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21.Cancer cell · 2010Article
- An essential role of PDCD4 in vascular smooth muscle cell apoptosis and proliferation: implications for vascular disease.American journal of physiology. Cell physiology · 2010Article
- MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction.The Journal of biological chemistry · 2009Article
- PDCD4 gene silencing in gliomas is associated with 5'CpG island methylation and unfavourable prognosis.Journal of cellular and molecular medicine · 2009Article
- PDCD4 inhibits the malignant phenotype of ovarian cancer cells.Cancer science · 2009Article
- MicroRNA-21 protects against the H(2)O(2)-induced injury on cardiac myocytes via its target gene PDCD4.Journal of molecular and cellular cardiology · 2009Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
The long-term survival of lung cancer patients treated with conventional therapies remains poor and therefore the need for novel approaches remains high. This has led to the re-emergence of aerosol delivery as a therapeutic intervention. In this study, glucosylated polyethylenimine (GPEI) was used as carrier to investigate programmed cell death 4 (PDCD4) and PDCD4 mutant (D418A), an eIF4A-binding mutant, on PDCD4-related signaling and activator protein-1 (AP-1) activity in the lungs of AP-1 luciferase reporter mice. After confirming the efficiency of GPEI as a carrier in lungs, the effects of aerosol-delivered PDCD4 were investigated in AP-1 luciferase reporter mice. Aerosol delivery of GPEI/PDCD4 through a nose-only inhalation facilitated the apoptosis of lungs whereas aerosol PDCD4 mutant did not. Also, such aerosol delivery regulated proteins relevant to cell-cycle control and suppressed AP-1 activity. Results obtained by western blot analysis, immunohistochemistry, luciferase assay and deoxynucleotidyl-transferase-mediated nick end labeling study suggest that combined actions such as facilitating apoptosis, controlling cell cycle and suppression of AP-1 activity by PDCD4 may provide useful tool for designing lung tumor prevention and treatment by which PDCD4 functions as a transformation suppressor in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.