ArticleDNA repair2007
The roles of Rad16 and Rad26 in repairing repressed and actively transcribed genes in yeast.
Article in DNA repair, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Loss of Heterozygosity associated with ubiquitous environments in yeast.PLoS genetics · 2025Article
- Elf1 promotes transcription-coupled repair in yeast by using its C-terminal domain to bind TFIIH.Nature communications · 2024Article
- Article
- Regulation of UV damage repair in quiescent yeast cells.DNA repair · 2020Article
- Organization of DNA damage, excision repair, and mutagenesis in chromatin: A genomic perspective.DNA repair · 2019Review
- RNA polymerase II depletion promotes transcription of alternative mRNA species.BMC molecular biology · 2016Article
- UV damage-induced RNA polymerase II stalling stimulates H2B deubiquitylation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Detection of an altered heterochromatin structure in the absence of the nucleotide excision repair protein Rad4 in Saccharomyces cerevisiae.Cell cycle (Georgetown, Tex.) · 2013Article
- Implication of posttranslational histone modifications in nucleotide excision repair.International journal of molecular sciences · 2012Review
- Diverse roles of RNA polymerase II-associated factor 1 complex in different subpathways of nucleotide excision repair.The Journal of biological chemistry · 2011Article
- Evidence that the histone methyltransferase Dot1 mediates global genomic repair by methylating histone H3 on lysine 79.The Journal of biological chemistry · 2011Article
- Chromatin structure and DNA damage repair.Epigenetics & chromatin · 2008Article
- Allelism of Saccharomyces cerevisiae gene PSO10, involved in error-prone repair of psoralen-induced DNA damage, with SUMO ligase-encoding MMS21.Current genetics · 2008Article
- Article
- Illuminating genome repair by photolyase.Photochemistry and photobiologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Nucleotide excision repair (NER) is a conserved DNA repair mechanism capable of removing a variety of helix-distorting DNA lesions. Rad26, a member of the Swi2/Snf2 superfamily of proteins, has been shown to be involved in a specialized NER process called transcription coupled NER. Rad16, another member of the same protein superfamily, has been shown to be required for genome-wide NER. Here we show that Rad16 and Rad26 play different roles in repairing repressed and actively transcribed genes in yeast. Rad16 is partially dispensable, and Rad26 plays a significant role in repairing certain regions of the repressed GAL1-10, PHO5 and ADH2 genes, especially in the core DNA of well-positioned nucleosomes. Simultaneous elimination of Rad16 and Rad26 results in no detectable repair in these regions of the repressed genes. Transcriptional induction of the GAL1-10 genes abolishes the role of Rad26, but does not affect the role of Rad16 in repairing the nontranscribed strand of the genes. Interestingly, when the transcription activator Gal4 is eliminated from the cells, Rad16 becomes partially dispensable and Rad26 plays a significant role in repairing both strands of the GAL1-10 genes even under inducing conditions. Our results suggest that Rad16 and Rad26 play different and, to some extent, complementary roles in repairing both strands of repressed genes, although the relative contributions of the two proteins can be different from gene to gene, and from region to region of a gene. However, Rad16 is solely responsible for repairing the nontranscribed strand of actively transcribed genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.