ArticleVirology2007
In vivo tumorigenesis by Jaagsiekte sheep retrovirus (JSRV) requires Y590 in Env TM, but not full-length orfX open reading frame.
Article in Virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Integrated Proteomic and Metabolomic Analyses Characterise Molecular Alterations Associated with JSRV-Induced OPA.Biology · 2026Article
- Loss of ENTV-2 RNA and Point Mutation ofAdvances in virology · 2026Article
- Exogenous Jaagsiekte sheep retrovirus (JSRV) Inner Mongolia strain: whole-genome characterization and viral particle packaging.Frontiers in veterinary science · 2025Article
- Article
- Association between genetic clades and cancer prevalence suggested by French-wide study of oncogenic small ruminant β-retrovirus diversity.Frontiers in cellular and infection microbiology · 2024Article
- Molecular detection of mixed infection with peste des petits ruminants and retroviruses in Egyptian sheep and goats.Tropical animal health and production · 2023Article
- Enzootic nasal tumor virus type 2 envelope of goats acts as a retroviral oncogene in cell transformation.Virus genes · 2021Article
- Transcriptional Response of Ovine Lung to Infection with Jaagsiekte Sheep Retrovirus.Journal of virology · 2019Article
- Ovine Pulmonary Adenocarcinoma: A Unique Model to Improve Lung Cancer Research.Frontiers in oncology · 2019Review
- Full-length genome sequence analysis of enzootic nasal tumor virus isolated from goats in China.Virology journal · 2017Article
- Role for a Zinc Finger Protein (Zfp111) in Transformation of 208F Rat Fibroblasts by Jaagsiekte Sheep Retrovirus Envelope Protein.Journal of virology · 2015Article
- Exploiting ovine immunology to improve the relevance of biomedical models.Molecular immunology · 2015Article
- The cytoplasmic tail of retroviral envelope glycoproteins.Progress in molecular biology and translational science · 2015Review
- "Ménage à Trois": the evolutionary interplay between JSRV, enJSRVs and domestic sheep.Viruses · 2014Review
- Host species barriers to Jaagsiekte sheep retrovirus replication and carcinogenesis.Journal of virology · 2013Article
- Jaagsiekte sheep retrovirus infects multiple cell types in the ovine lung.Journal of virology · 2011Article
- Functional interaction between Env oncogene from Jaagsiekte sheep retrovirus and tumor suppressor Sprouty2.Retrovirology · 2010Article
- Friendly viruses: the special relationship between endogenous retroviruses and their host.Annals of the New York Academy of Sciences · 2009Article
- XMRV is present in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- First confirmation by PCR of Jaagsiekte sheep retrovirus in Ireland and prevalence of ovine pulmonary adenocarcinoma in adult sheep at slaughter.Irish veterinary journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Jaagsiekte retrovirus (JSRV) causes ovine pulmonary adenocarcinoma (OPA), a transmissible lung cancer of sheep. The envelope (Env) glycoprotein protein of JSRV functions as a dominant oncoprotein in vitro and in vivo. An SH2 binding domain (YXXM) in the cytoplasmic tail of the JSRV Env is one of the main determinants of viral transformation at least in vitro. In these studies, we report the first in vivo tests of site-specific mutants of JSRV in their natural host, the sheep. We show that, in vivo, JSRV(21) with the cytoplasmic tail YXXM mutated to DXXM did not cause disease nor detectable infection, indicating that this motif is absolutely required for virus replication and possibly transformation in vivo. In contrast, mutation of the JSRV open reading frame orfX, for which no function has yet been attributed, did not alter the disease induced by JSRV(21).
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.