ArticleBMC musculoskeletal disorders2007
Pedigree analysis and epidemiological features of idiopathic congenital talipes equinovarus in the United Kingdom: a case-control study.
Article in BMC musculoskeletal disorders, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 5 of them syntheses that pooled it.
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25 citing papers in PubMed, 5 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Management of idiopathic clubfoot: an umbrella review and CPAM-LRC consensus: Limb Reconstruction Committee of Orthopedics Branch of China International Exchange and Promotion Association for Medical and Health Care (CPAM-LRC).Journal of orthopaedic surgery and research · 2025Pooled it
- Effectiveness of the ponseti method in treating neurogenic clubfoot: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- A thorough analysis of data on the correlation between COL9A1 polymorphisms and the susceptibility to congenital talipes equinovarus: a meta-analysis.Journal of orthopaedic surgery and research · 2024Pooled it
- The etiology of idiopathic congenital talipes equinovarus: a systematic review.Journal of orthopaedic surgery and research · 2018Pooled it
- Maternal smoking in pregnancy and birth defects: a systematic review based on 173 687 malformed cases and 11.7 million controls.Human reproduction updatePooled it
- Association between video-based Pirani Böhm Sinclair score and treatment recommendations in recurrent clubfoot in walking-age children.Journal of orthopaedic surgery and research · 2026Observational
- Risk Factors of Idiopathic Congenital Clubfoot in the South of Vietnam: A Hospital-Based Study.Cureus · 2025Article
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- The Incidence of Clubfoot in the Czech Republic: A Nationwide Epidemiological Study from 2000 to 2014.Children (Basel, Switzerland) · 2023Article
- Birth Anomalies in Monozygotic and Dizygotic Twins: Results From the California Twin Registry.Journal of epidemiology · 2019Article
- Association between maternal age at conception and risk of idiopathic clubfoot.Acta orthopaedica · 2016Article
- Maternal cigarette, alcohol, and coffee consumption in relation to risk of clubfoot.Paediatric and perinatal epidemiology · 2015Article
- Medication use in pregnancy in relation to the risk of isolated clubfoot in offspring.American journal of epidemiology · 2014Article
- Descriptive epidemiology of idiopathic clubfoot.American journal of medical genetics. Part A · 2013Article
- Identification of an FHL1 protein complex containing gamma-actin and non-muscle myosin IIB by analysis of protein-protein interactions.PloS one · 2013Article
- Descriptive epidemiology of clubfoot in Peru: a clinic-based study.The Iowa orthopaedic journal · 2013Article
- Descriptive epidemiology of clubfoot in Vietnam: a clinic-based study.The Iowa orthopaedic journal · 2012Article
- Article
- Smoking, the xenobiotic pathway, and clubfoot.Birth defects research. Part A, Clinical and molecular teratology · 2011Article
- Micro-magnetic resonance imaging and embryological analysis of wild-type and pma mutant mice with clubfoot.Journal of anatomy · 2010Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCongenital talipes equinovarus (CTEV) is a common developmental disorder of the foot, affecting between 1 and 4.5 per 1000 live births. The aetiology is not well elucidated. While both genetic and environmental factors are implicated, no specific genes have been identified and little is known about environmental risk factors.
methodsWe conducted a case-control study of idiopathic congenital talipes equinovarus (ICTEV) in the United Kingdom. 194 cases and 60 controls were recruited. Pedigrees were obtained for 167 cases.
resultsThe rank of the index pregnancy, maternal education and caesarean delivery were significantly associated with ICTEV risk in a multivariate model. There were suggestions that maternal use of folic acid supplements in the three months before the pregnancy decreased ICTEV risk, and that parental smoking during the pregnancy increased risk, although the associations were not statistically significant. One quarter of pedigrees showed a family history of CTEV, and autosomal dominant inheritance was suggested in some of these.
conclusionUterine restriction did not appear to have a strong influence on ICTEV development in our study. Large population-based studies are needed to clarify the aetiology of this common developmental disorder.
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