ArticleRespiratory research2007
Phenotypic alterations in type II alveolar epithelial cells in CD4+ T cell mediated lung inflammation.
Article in Respiratory research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Chronic lung inflammation primes humoral immunity and augments antipneumococcal resistance.Scientific reports · 2017Article
- Whole genome sequencing identifies missense mutation in MTBP in Shar-Pei affected with Autoinflammatory Disease (SPAID).BMC genomics · 2017Article
- Identification of a Predominantly Interferon-λ-Induced Transcriptional Profile in Murine Intestinal Epithelial Cells.Frontiers in immunology · 2017Article
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- Caspase-1-dependent and -independent cell death pathways in Burkholderia pseudomallei infection of macrophages.PLoS pathogens · 2014Article
- Attenuation of immune-mediated influenza pneumonia by targeting the inducible co-stimulator (ICOS) molecule on T cells.PloS one · 2014Article
- IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia.International immunology · 2013Article
- COPD is associated with production of autoantibodies to a broad spectrum of self-antigens, correlative with disease phenotype.Immunologic research · 2013Article
- Flow cytometric isolation of primary murine type II alveolar epithelial cells for functional and molecular studies.Journal of visualized experiments : JoVE · 2012Article
- PCR based bronchoscopic detection of common respiratory pathogens in chronic cough: a case control study.Cough (London, England) · 2012Article
- Impact of enzymatic tissue disintegration on the level of surface molecule expression and immune cell function.European journal of microbiology & immunology · 2012Article
- Ethanol exposure impairs LPS-induced pulmonary LIX expression: alveolar epithelial cell dysfunction as a consequence of acute intoxication.Alcoholism, clinical and experimental research · 2009Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the contribution of alveolar type II epithelial cell (AEC II) activities in various aspects of respiratory immune regulation has become increasingly appreciated, our understanding of the contribution of AEC II transcriptosome in immunopathologic lung injury remains poorly understood. We have previously established a mouse model for chronic T cell-mediated pulmonary inflammation in which influenza hemagglutinin (HA) is expressed as a transgene in AEC II, in mice expressing a transgenic T cell receptor specific for a class II-restricted epitope of HA. Pulmonary inflammation in these mice occurs as a result of CD4+ T cell recognition of alveolar antigen. This model was utilized to assess the profile of inflammatory mediators expressed by alveolar epithelial target cells triggered by antigen-specific recognition in CD4+ T cell-mediated lung inflammation.
methodsWe established a method that allows the flow cytometric negative selection and isolation of primary AEC II of high viability and purity. Genome wide transcriptional profiling was performed on mRNA isolated from AEC II isolated from healthy mice and from mice with acute and chronic CD4+ T cell-mediated pulmonary inflammation.
resultsT cell-mediated inflammation was associated with expression of a broad array of cytokine and chemokine genes by AEC II cell, indicating a potential contribution of epithelial-derived chemoattractants to the inflammatory cell parenchymal infiltration. Morphologically, there was an increase in the size of activated epithelial cells, and on the molecular level, comparative transcriptome analyses of AEC II from inflamed versus normal lungs provide a detailed characterization of the specific inflammatory genes expressed in AEC II induced in the context of CD4+ T cell-mediated pneumonitis.
conclusionAn important contribution of AEC II gene expression to the orchestration and regulation of interstitial pneumonitis is suggested by the panoply of inflammatory genes expressed by this cell population, and this may provide insight into the molecular pathogenesis of pulmonary inflammatory states. CD4+ T cell recognition of antigen presented by AEC II cells appears to be a potent trigger for activation of the alveolar cell inflammatory transcriptosome.
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