ArticleJournal of Zhejiang University. Science. B2007
Preimplantation genetic diagnosis for Down syndrome pregnancy.
Article in Journal of Zhejiang University. Science. B, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed, 7 citations in OpenAlex.
- Accuracy of a combined score of zygote and embryo morphology for selecting the best embryos for IVF.Journal of Zhejiang University. Science. B · 2008Trial
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effect of preimplantation genetic diagnosis (PGD) conducted for women who had Down syndrome pregnancy previously.
methodsTrisomy 21 was diagnosed by using fluorescence in site hybridization (FISH) before embryo transfer in two women who had Down syndrome pregnancies. Each received one or two PGD cycles respectively.
resultsCase 1: one PGD cycle was conducted, two oocytes were fertilized and biopsied. One embryo is of trisomy 21 and the other of monosomy 21. No embryo was transferred. Case 2: two PGD cycles were conducted, in total, sixteen oocytes were fertilized and biopsied. Four embryos were tested to be normal, six of trisomy 21, and one of monosomy 21. Five had no signal. Four normal embryos were transferred but no pregnancy resulted.
conclusionFor couples who had pregnancies with Down syndrome previously, PGD can be considered, and has been shown to be an effective strategy.
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