ArticleIntensive care medicine2007
Replacement of 24-h creatinine clearance by 2-h creatinine clearance in intensive care unit patients: a single-center study.
Article in Intensive care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed.
- Population pharmacokinetics of imipenem in critically ill patients with suspected ventilator-associated pneumonia and evaluation of dosage regimens.British journal of clinical pharmacology · 2014Trial
- Four hour creatinine clearance is better than plasma creatinine for monitoring renal function in critically ill patients.Critical care (London, England) · 2012Trial
- Discontinuation of continuous kidney replacement therapy in patients with acute kidney injury: A pilot study.Journal of critical care · 2026Article
- Challenges and opportunities in the management of severe pneumonia. Key concepts from the Seventh Annual Meeting of Spanish Experts 2025.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026Review
- Evaluation of 6-hour urine creatinine clearance as the kidney component in the SOFA score: An observational cohort study.Journal of intensive medicine · 2026Article
- Hypophosphatemia-factors associated with its development and 90-day mortality effect: a prospective observational study.Frontiers in medicine · 2026Article
- The long walk to a short half-life: the discovery of augmented renal clearance and its impact on antibiotic dosing.The Journal of antimicrobial chemotherapy · 2025Review
- β-Lactam/β-Lactamase Inhibitor Combinations in Sepsis-Associated Acute Kidney Injury and Renal Replacement Therapy.Antibiotics (Basel, Switzerland) · 2025Review
- Renal profile and the associated outcome of patients with acute kidney injury undergoing dialysis in Renal Unit at a Tertiary Healthcare Facility in Western Kenya.African health sciences · 2025Article
- Article
- Update on Therapeutic Drug Monitoring of Beta-Lactam Antibiotics in Critically Ill Patients-A Narrative Review.Antibiotics (Basel, Switzerland) · 2023Review
- Augmented renal clearance in the ICU: estimation, incidence, risk factors and consequences-a retrospective observational study.Annals of intensive care · 2022Article
- The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020).Journal of intensive care · 2021Article
- Acute kidney injury.Nature reviews. Disease primers · 2021Review
- Assessment of kidney proximal tubular secretion in critical illness.JCI insight · 2021Article
- [New kidney function tests: Renal functional reserve and furosemide stress test].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2020Review
- Area under the Curve-Based Dosing of Vancomycin in Critically Ill Patients Using 6-Hour Urine Creatinine Clearance Measurement.Critical care research and practice · 2020Article
- Augmented renal clearance is associated with inadequate antibiotic pharmacokinetic/pharmacodynamic target in Asian ICU population: a prospective observational study.Infection and drug resistance · 2019Article
- Issues of Acute Kidney Injury Staging and Management in Sepsis and Critical Illness: A Narrative Review.International journal of molecular sciences · 2017Review
- Acute Kidney Injury: Diagnostic Approaches and Controversies.The Clinical biochemist. Reviews · 2016Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo estimate the usefulness of 2-h creatinine clearance (CrCl) in the ICU and define variables that may reduce agreement.
designProspective study.
settingPolyvalent ICU of a university hospital. PATIENTS: 359 patients.
interventionsWe compared 24-h CrCl (CrCl-24h), as the standard measure, with 2-h CrCl (CrCl-2h) (at the start of the period) and the Cockroft-Gault equation (Ck-G). MEASUREMENTS AND
resultsThe 2-h sample was lost in two patients (0.6%) and the 24-h sample was lost in 50 patients (13.9%). The mean Ck-G was 87.4+/-3.05, with CrCl-2h 109.2+/-4.46 and CrCl-24h 100.9+/-4.21 ml/min/1.73 m2 (r2 of 0.88 for CrCl-2h and 0.84 for Ck-G). The differences from ClCr-24h were 21.8+/-3.3 (p<0.001) for the Ck-G and 8.3+/-2.6 (p<0.05) for CrCl-2h (p<0.05). In the subgroup of patients with CrCl-24h<100 ml/min/1.73 m2, the CrCl-24h value was 52.9+/-2.71 vs. 51.6+/-2.14 for CrCl-2h (p=ns) and 57.6+/-2.56 (p<0.001) for the Ck-G. Patients with CrCl<100 ml/min only showed variability in hyperglycemia during the 24-h period.
conclusionsIn intensive care patients, 24-h CrCl results in a large proportion of non-valid determinations, even under conditions of close monitoring. Two-hour CrCl is an adequate substitute, even in patients who are unstable or who have irregular diuresis where a 24-h collection is impossible. The Cockroft-Gault equation seems less useful in this setting.
Indexed as
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Registered trials
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