ArticleProceedings of the National Academy of Sciences of the United States of America2007
TNF-induced structural joint damage is mediated by IL-1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.
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111 citing papers in PubMed, 296 citations in OpenAlex.
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- The effect of Rsk2 on TNFα-mediated bone loss in the TMJ and craniofacial skeleton.BMC oral health · 2025Article
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- Molecular Mechanisms of Immunoinflammatory Infiltration and Ferroptosis in Arthritis Revealed by a Combination of Bioinformatics and Single-Cell Analysis.Journal of inflammation research · 2025Article
- A multidimensional analysis of temporomandibular joint and ankle joint erosion in inflammatory arthritis.Frontiers in immunology · 2025Article
- The role of exercise in aromatase inhibitor-induced arthralgia.PM & R : the journal of injury, function, and rehabilitation · 2024Review
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- The multi-faceted nature of age-associated osteoporosis.Bone reports · 2024Review
- Role of Interleukin-36 in inflammatory joint diseases.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2023Review
- Molecular Basis beyond Interrelated Bone Resorption/Regeneration in Periodontal Diseases: A Concise Review.International journal of molecular sciences · 2023Review
- Effect of milk fat globules on growth and metabolism in rats fed an unbalanced diet.Frontiers in nutrition · 2023Article
- TNF overexpression and dexamethasone treatment impair chondrogenesis and bone growth in an additive manner.Scientific reports · 2022Article
- Autophagy Plays Multiple Roles in the Soft-Tissue Healing and Osseointegration in Dental Implant Surgery-A Narrative Review.Materials (Basel, Switzerland) · 2022Review
- Harpagoside attenuates local bone Erosion and systemic osteoporosis in collagen-induced arthritis in mice.BMC complementary medicine and therapies · 2022Article
51 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 7 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blocking TNF effectively inhibits inflammation and structural damage in human rheumatoid arthritis (RA). However, so far it is unclear whether the effect of TNF is a direct one or indirect on up-regulation of other mediators. IL-1 may be one of these candidates because it has a central role in animal models of arthritis, and inhibition of IL-1 is used as a therapy of human RA. We removed the effects of IL-1 from a TNF-mediated inflammatory joint disease by crossing IL-1alpha and beta-deficient mice (IL-1-/-) with arthritic human TNF-transgenic (hTNFtg) mice. Development of synovial inflammation was almost unaffected on IL-1 deficiency, but bone erosion and osteoclast formation were significantly reduced in IL-1-/-hTNFtg mice, compared with hTNFtg mice based on an intrinsic differentiation defect of IL-1-deficient monocytes. Most dramatically, however, cartilage damage was absent in IL-1-/-hTNFtg mice. Chimera studies revealed that protection of cartilage is based on the loss of IL-1 on hematopoietic, but not mesenchymal, cells, leading to decreased expression of ADAMTS-5 and MMP-3. These data show that TNF-mediated cartilage damage is completely and TNF-mediated bone damage is partially dependent on IL-1, suggesting that IL-1 is a crucial mediator for inflammatory cartilage and bone degradation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.