ArticleProceedings of the National Academy of Sciences of the United States of America2007
Telomerase core components protect Candida telomeres from aberrant overhang accumulation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 36 citations in OpenAlex.
- Flexible Attachment and Detachment of Centromeres and Telomeres to and from Chromosomes.Biomolecules · 2023Review
- Thyroid carcinoma-featured telomerase activation and telomere maintenance: Biology and translational/clinical significance.Clinical and translational medicine · 2022Review
- Telomeric and Sub-Telomeric Structure and Implications in Fungal Opportunistic Pathogens.Microorganisms · 2021Review
- Crystal structures of N-terminally truncated telomerase reverse transcriptase from fungi‡.Nucleic acids research · 2021Article
- Telomerase, the recombination machinery and Rap1 play redundant roles in yeast telomere protection.Current genetics · 2021Article
- Review
- Telomerase promotes formation of a telomere protective complex in cancer cells.Science advances · 2019Article
- Catalysis-dependent inactivation of human telomerase and its reactivation by intracellular telomerase-activating factors (iTAFs).The Journal of biological chemistry · 2019Article
- Article
- Direct observation of nucleic acid binding dynamics by the telomerase essential N-terminal domain.Nucleic acids research · 2018Article
- Brh2 and Rad51 promote telomere maintenance in Ustilago maydis, a new model system of DNA repair proteins at telomeres.DNA repair · 2013Article
- Identification of purple sea urchin telomerase RNA using a next-generation sequencing based approach.RNA (New York, N.Y.) · 2013Article
- An alternative telomerase RNA in Arabidopsis modulates enzyme activity in response to DNA damage.Genes & development · 2012Article
- Chromosome end protection by blunt-ended telomeres.Genes & development · 2012Article
- Est1 protects telomeres and inhibits subtelomeric y'-element recombination.Molecular and cellular biology · 2011Article
- Rad52 function prevents chromosome loss and truncation in Candida albicans.Molecular microbiology · 2011Article
- The Candida albicans Ku70 modulates telomere length and structure by regulating both telomerase and recombination.PloS one · 2011Article
- Dynamics of telomerase activity in response to acute psychological stress.Brain, behavior, and immunity · 2010Article
- Investigating the role of the Est3 protein in yeast telomere replication.Nucleic acids research · 2010Article
- Rap1 in Candida albicans: an unusual structural organization and a critical function in suppressing telomere recombination.Molecular and cellular biology · 2010Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Telomerase is a cellular reverse transcriptase that extends one strand (the G-strand) of the telomere terminal repeats. Aside from this role in telomere length maintenance, telomerase has been proposed to serve a protective function at chromosome ends, although this is not well understood mechanistically. Earlier analysis suggests that, in the pathogenic yeast Candida albicans, the catalytic reverse transcriptase subunit of telomerase (TERT/EST2) can protect telomeres against nucleolytic degradation. In this report we demonstrate that the RNA component (TER1) has a similar function; in addition to complete loss of telomerase activity and progressive telomere attrition, the ter1-DeltaDelta strains manifested a dramatic increase in the amount of G-strand overhangs, consistent with aberrant degradation of the complementary C-strand. We also demonstrate that a catalytically incompetent EST2 protein can suppress such overhang accumulation in the est2-DeltaDelta mutant to the same extent as the wild-type protein. Altogether, our data support the notion that the Candida telomerase core components mediate a protective function through a mechanism that is independent of its catalytic activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.