ArticleProceedings of the National Academy of Sciences of the United States of America2007
Peripheral deletion of mature alloreactive B cells induced by costimulation blockade.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Transplantation tolerance modifies donor-specific B cell fate to suppress de novo alloreactive B cells.The Journal of clinical investigation · 2020Article
- The contribution of B cells to transplantation tolerance.The Journal of clinical investigation · 2020Article
- Equal Expansion of Endogenous Transplant-Specific Regulatory T Cell and Recruitment Into the Allograft During Rejection and Tolerance.Frontiers in immunology · 2018Article
- Evolving Approaches in the Identification of Allograft-Reactive T and B Cells in Mice and Humans.Transplantation · 2017Review
- Transplantation tolerance: don't forget about the B cells.Clinical and experimental immunology · 2017Review
- Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Transplantation tolerance and its outcome during infections and inflammation.Immunological reviews · 2014Review
- Experimental models of B cell tolerance in transplantation.Seminars in immunology · 2012Review
- Innate and adaptive immune responses are tolerized in chimeras prepared with nonmyeloablative conditioning.Transplantation · 2012Article
- Essential role for B cells in transplantation tolerance.Current opinion in immunology · 2011Review
- B-cell tolerance in transplantation: is repertoire remodeling the answer?Expert review of clinical immunology · 2009Article
- Manipulating the immune system for anti-tumor responses and transplant tolerance via mixed hematopoietic chimerism.Immunological reviews · 2008Review
- Long-term control of alloreactive B cell responses by the suppression of T cell help.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Blockade of both B7-H4 and CTLA-4 co-signaling pathways enhances mouse islet allograft survival.IsletsArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Alloreactive B cells can contribute to graft rejection. Anti-CD154 treatment together with donor-specific transfusion (DST) results in the long-term survival of MHC-mismatched mouse heart grafts and inhibition of alloantibody production. To characterize the mechanism of B cell tolerance induced by the anti-CD154 and DST, we used 3-83Igi mice, on BALB/c (H-2K(d)) background, that express a B cell receptor that reacts with MHC class I antigens H-2K(b). Transplanting C57BL/6 (H-2K(b)) hearts into 3-83Igi mice, followed by tolerance induction, resulted in the peripheral deletion of mature but not immature 3-83 B cells. The sustained deletion of mature alloreactive B cells required the presence of the allograft and can be explained by the absence of T cell help.
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