ArticleJournal of the Royal Society, Interface2008
Transmission electron microscopy study of the cell-sensor interface.
Article in Journal of the Royal Society, Interface, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Numerical investigation of a graphene-on-semiconductor device for optical monitoring of cell electrophysiology.iScience · 2024Article
- Low Surface Potential with Glycoconjugates Determines Insect Cell Adhesion at Room Temperature.The journal of physical chemistry letters · 2022Article
- Advances in Cell-Conductive Polymer Biointerfaces and Role of the Plasma Membrane.Chemical reviews · 2022Article
- Tutorial: using nanoneedles for intracellular delivery.Nature protocols · 2021Review
- Adhesion of Triple-Negative Breast Cancer Cells under Fluorescent and Soft X-ray Contact Microscopy.International journal of molecular sciences · 2021Article
- Ultrastructural Analysis of Neuroimplant-Parenchyma Interfaces Uncover Remarkable Neuroregeneration Along-With Barriers That Limit the Implant Electrophysiological Functions.Frontiers in neuroscience · 2021Article
- Immunohistological and Ultrastructural Study of the Inflammatory Response to Perforated Polyimide Cortical Implants: Mechanisms Underlying Deterioration of Electrophysiological Recording Quality.Frontiers in neuroscience · 2020Article
- Electron Microscopy for 3D Scaffolds-Cell Biointerface Characterization.Advanced biosystems · 2019Article
- Inorganic semiconductor biointerfaces.Nature reviews. Materials · 2018Article
- Single-layer graphene modulates neuronal communication and augments membrane ion currents.Nature nanotechnology · 2018Article
- Interfacing Cells with Vertical Nanoscale Devices: Applications and Characterization.Annual review of analytical chemistry (Palo Alto, Calif.) · 2018Review
- Imaging analysis of the interface between osteoblasts and microrough surfaces of laser-sintered titanium alloy constructs.Journal of microscopy · 2018Article
- Increasing cell-device adherence using cultured insect cells for receptor-based biosensors.Royal Society open science · 2018Article
- Revealing the Cell-Material Interface with Nanometer Resolution by Focused Ion Beam/Scanning Electron Microscopy.ACS nano · 2017Article
- A novel bio-mimicking, planar nano-edge microelectrode enables enhanced long-term neural recording.Scientific reports · 2016Article
- Nano-Bioelectronics.Chemical reviews · 2016Review
- Multi-electrode array technologies for neuroscience and cardiology.Nature nanotechnology · 2013Review
- Mapping the complex morphology of cell interactions with nanowire substrates using FIB-SEM.PloS one · 2013Article
- Spine-shaped gold protrusions improve the adherence and electrical coupling of neurons with the surface of micro-electronic devices.Journal of the Royal Society, Interface · 2009Article
- Coupling of semiconductor nanowires with neurons and their interfacial structure.Nanoscale research letters · 2009Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An emerging number of micro- and nanoelectronics-based biosensors have been developed for non-invasive recordings of physiological cellular activity. The interface between the biological system and the electronic devices strongly influences the signal transfer between these systems. Little is known about the nanoscopic structure of the cell-sensor interface that is essential for a detailed interpretation of the recordings. Therefore, we analysed the interface between the sensor surface and attached cells using transmission electron microscopy (TEM). The maximum possible resolution of our TEM study, however, was restricted by the quality of the interface preparation. Therefore, we complemented our studies with imaging ellipsometry. We cultured HEK293 cells on substrates, which had been precoated with different types of proteins. We found that contact geometry between attached cell membrane and substrate was dependent on the type of protein coating used. In the presence of polylysine, the average distance of the membrane-substrate interface was in the range of 35-40 nm. However, the cell membrane was highly protruded in the presence of other proteins like fibronectin, laminin or concanavalin-A. The presented method allows the nanoscopic characterization of the cell-sensor interface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.