ArticleImmunology2007
Over-expression of the bovine FcRn in the mammary gland results in increased IgG levels in both milk and serum of transgenic mice.
Article in Immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Magnesium-L-threonate Ameliorates Cognitive Deficit by Attenuating Adult Hippocampal Neurogenesis Impairment in a Mouse Model of Alzheimer's Disease.Experimental neurobiology · 2025Article
- Deciphering the colostral-immunity transfer: from mammary gland to neonates small intestine.Veterinary research communications · 2025Review
- The Expression of Non B Cell-Derived Immunoglobulins.Advances in experimental medicine and biology · 2024Review
- Maternal antibiotic treatment during pregnancy attenuates the transport and absorption of maternal antibody IgG through TLR4 and TLR2 receptor.Frontiers in microbiology · 2023Article
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- Temporal kinetics of bovine mammary IgG secretion into colostrum and transition milk.Journal of animal science · 2021Article
- Transcriptional profiling of swine mammary gland during the transition from colostrogenesis to lactogenesis using RNA sequencing.BMC genomics · 2018Article
- TGEV infection up-regulates FcRn expression via activation of NF-κB signaling.Scientific reports · 2016Article
- Immunoglobulin Transporting Receptors Are Potential Targets for the Immunity Enhancement and Generation of Mammary Gland Bioreactor.Frontiers in immunology · 2016Review
- Targeting FcRn for therapy: from live cell imaging to in vivo studies in mice.Immunology letters · 2014Review
- Colostrogenesis: IgG1 transcytosis mechanisms.Journal of mammary gland biology and neoplasia · 2014Review
- Bovine FcRn-mediated human immunoglobulin G transfer across the milk-blood barrier in transgenic mice.PloS one · 2014Article
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- Article
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- Monoclonal antibodies as pharmacokinetic antagonists for the treatment of (+)-methamphetamine addiction.CNS & neurological disorders drug targets · 2011Review
- Perspectives on immunoglobulins in colostrum and milk.Nutrients · 2011Review
- The fate and function of therapeutic antiaddiction monoclonal antibodies across the reproductive cycle of rats.The Journal of pharmacology and experimental therapeutics · 2011Article
- Neonatal Fc receptor: from immunity to therapeutics.Journal of clinical immunology · 2010Review
- Immunoglobulin gene locus events in epithelial cells of lactating mouse mammary glands.Cellular and molecular life sciences : CMLS · 2010Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neonatal Fc receptor (FcRn) protects immunoglobulin G (IgG) from catabolism and is also responsible for IgG absorption in the neonatal small intestine. However, whether it mediates the transfer of IgG from plasma to milk still remains speculative. In the present study, we have generated transgenic mice that over-express the bovine FcRn (bFcRn) in their lactating mammary glands. Significantly increased IgG levels were observed in the sera and milk from transgenic animals, suggesting that the over-expressed bFcRn could bind and protect endogenous mouse IgG and thus extend its lifespan. We also found that injected human IgG showed a significantly longer half-life (7-8 days) in the transgenic mice than in controls (2.9 days). Altogether, the data suggested that bFcRn could bind both mouse and human IgG, showing a cross-species FcRn-IgG binding activity. However, we found no selective accumulation of endogenous mouse IgG or injected bovine IgG in the milk of the transgenic females, supporting a previous hypothesis that IgG was transported from serum to milk in an inverse correlation to its binding affinity to FcRn.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.