ArticlePLoS biology2007
Topological reorganization of odor representations in the olfactory bulb.
Article in PLoS biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed.
- Topographically organized dorsal raphe activity modulates forebrain sensory-motor representations and contributes to defensive behaviors.Nature communications · 2026Article
- Functional odor map heterogeneity is based on multifaceted glomerular connectivity in larvaliScience · 2023Article
- Deep imaging in the brainstem reveals functional heterogeneity in V2a neurons controlling locomotion.Science advances · 2020Article
- Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis.Science advances · 2020Article
- Stimulus-specific behavioral responses of zebrafish to a large range of odors exhibit individual variability.BMC biology · 2020Article
- Interhemispheric connections between olfactory bulbs improve odor detection.PLoS biology · 2020Article
- Whitening of odor representations by the wiring diagram of the olfactory bulb.Nature neuroscience · 2020Article
- Zebrafish: an emerging real-time model system to study Alzheimer's disease and neurospecific drug discovery.Cell death discovery · 2018Article
- Methods for Mapping Neuronal Activity to Synaptic Connectivity: Lessons From Larval Zebrafish.Frontiers in neural circuits · 2018Article
- Reduced Lateral Inhibition Impairs Olfactory Computations and Behaviors in a Drosophila Model of Fragile X Syndrome.Current biology : CB · 2017Article
- 3-dimensional electron microscopic imaging of the zebrafish olfactory bulb and dense reconstruction of neurons.Scientific data · 2016Article
- Exposure to Zinc Sulfate Results in Differential Effects on Olfactory Sensory Neuron Subtypes in Adult Zebrafish.International journal of molecular sciences · 2016Article
- Dense EM-based reconstruction of the interglomerular projectome in the zebrafish olfactory bulb.Nature neuroscience · 2016Article
- Neuronal pattern separation in the olfactory bulb improves odor discrimination learning.Nature neuroscience · 2015Article
- Plasticity of glomeruli and olfactory-mediated behavior in zebrafish following detergent lesioning of the olfactory epithelium.Neuroscience · 2015Article
- Functional transformations of odor inputs in the mouse olfactory bulb.Frontiers in neural circuits · 2014Article
- Equalization of odor representations by a network of electrically coupled inhibitory interneurons.Nature neuroscience · 2013Article
- Optical dissection of odor information processing in vivo using GCaMPs expressed in specified cell types of the olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Article
- Analyzing the structure and function of neuronal circuits in zebrafish.Frontiers in neural circuits · 2013Review
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Odors are initially represented in the olfactory bulb (OB) by patterns of sensory input across the array of glomeruli. Although activated glomeruli are often widely distributed, glomeruli responding to stimuli sharing molecular features tend to be loosely clustered and thus establish a fractured chemotopic map. Neuronal circuits in the OB transform glomerular patterns of sensory input into spatiotemporal patterns of output activity and thereby extract information about a stimulus. It is, however, unknown whether the chemotopic spatial organization of glomerular inputs is maintained during these computations. To explore this issue, we measured spatiotemporal patterns of odor-evoked activity across thousands of individual neurons in the zebrafish OB by temporally deconvolved two-photon Ca(2+) imaging. Mitral cells and interneurons were distinguished by transgenic markers and exhibited different response selectivities. Shortly after response onset, activity patterns exhibited foci of activity associated with certain chemical features throughout all layers. During the subsequent few hundred milliseconds, however, MC activity was locally sparsened within the initial foci in an odor-specific manner. As a consequence, chemotopic maps disappeared and activity patterns became more informative about precise odor identity. Hence, chemotopic maps of glomerular input activity are initially transmitted to OB outputs, but not maintained during pattern processing. Nevertheless, transient chemotopic maps may support neuronal computations by establishing important synaptic interactions within the circuit. These results provide insights into the functional topology of neural activity patterns and its potential role in circuit function.
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