ArticlePLoS biology2007
Comparison of C. elegans and C. briggsae genome sequences reveals extensive conservation of chromosome organization and synteny.
Article in PLoS biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.
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117 citing papers in PubMed.
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- Population structure and punctuated genomic hyper-diversity in Caenorhabditis briggsae.Molecular biology and evolution · 2026Article
- Programmed DNA elimination was present in the last common ancestor ofbioRxiv : the preprint server for biology · 2026Article
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- Allelic Variation at tRNA Genes in Three Nematode Species Indicates Mutation Load Despite Strong Purifying Selection.Genome biology and evolution · 2026Article
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- An SRR1 domain-containing protein is required for efficient Orsay virus replication inJournal of virology · 2025Article
- Heat tolerance and genetic adaptations in Caenorhabditis briggsae: insights from comparative studies with Caenorhabditis elegans.Genetics · 2025Article
- Genome-Wide Temporal Gene Expression Reveals a Post-Reproductive Shift in the Nematode Caenorhabditis briggsae.Genome biology and evolution · 2025Article
- Pervasive Conservation of Intron Number and Other Genetic Elements Revealed by a Chromosome-level Genome Assembly of the Hyper-polymorphic Nematode Caenorhabditis brenneri.Genome biology and evolution · 2025Article
- Visualizing genomic evolution in Caenorhabditis through WormSynteny.BMC genomics · 2024Article
- Gene duplication and evolutionary plasticity of lin-12/Notch gene function in Caenorhabditis.Genetics · 2024Article
- Pervasive conservation of intron number and other genetic elements revealed by a chromosome-level genomic assembly of the hyper-polymorphic nematodebioRxiv : the preprint server for biology · 2024Article
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- Natural variation in infection specificity of Caenorhabditis briggsae isolates by two RNA viruses.PLoS pathogens · 2024Article
- Syntenic relationship of chromosomes inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
57 more citing papers are in PubMed but not listed here.
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7 authors.
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Abstract
To determine whether the distinctive features of Caenorhabditis elegans chromosomal organization are shared with the C. briggsae genome, we constructed a single nucleotide polymorphism-based genetic map to order and orient the whole genome shotgun assembly along the six C. briggsae chromosomes. Although these species are of the same genus, their most recent common ancestor existed 80-110 million years ago, and thus they are more evolutionarily distant than, for example, human and mouse. We found that, like C. elegans chromosomes, C. briggsae chromosomes exhibit high levels of recombination on the arms along with higher repeat density, a higher fraction of intronic sequence, and a lower fraction of exonic sequence compared with chromosome centers. Despite extensive intrachromosomal rearrangements, 1:1 orthologs tend to remain in the same region of the chromosome, and colinear blocks of orthologs tend to be longer in chromosome centers compared with arms. More strikingly, the two species show an almost complete conservation of synteny, with 1:1 orthologs present on a single chromosome in one species also found on a single chromosome in the other. The conservation of both chromosomal organization and synteny between these two distantly related species suggests roles for chromosome organization in the fitness of an organism that are only poorly understood presently.
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