ArticleGenetica2008
Testing the rare-alleles model of quantitative variation by artificial selection.
Article in Genetica, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Adaptive transgenerational plasticity through priming in response to neighbor density in Mimulus platycalyx.PloS one · 2026Article
- Weak response to selection on stigma-anther distance in a primarily selfing population of yellow monkeyflower.Proceedings. Biological sciences · 2024Article
- Experimental evolution suggests rapid assembly of the 'selfing syndrome' from standing variation inFrontiers in plant science · 2024Article
- The genomic scale of fluctuating selection in a natural plant population.Evolution letters · 2022Article
- Pollinator loss causes rapid adaptive evolution of selfing and dramatically reduces genome-wide genetic variability.Evolution; international journal of organic evolution · 2022Article
- Predicting evolutionary change at the DNA level in a natural Mimulus population.PLoS genetics · 2021Article
- Evaluating the genetic architecture of quantitative traits via selection followed by inbreeding.Heredity · 2019Article
- Molecular evidence supports a genic capture resolution of the lek paradox.Nature communications · 2019Article
- A Segregating Inversion Generates Fitness Variation in Yellow Monkeyflower (Mimulus guttatus).Genetics · 2016Article
- Epistasis Is a Major Determinant of the Additive Genetic Variance in Mimulus guttatus.PLoS genetics · 2015Article
- The genomic signal of partial sweeps in Mimulus guttatus.Genome biology and evolution · 2013Article
- Spatially and temporally varying selection on intrapopulation quantitative trait loci for a life history trade-off in Mimulus guttatus.Molecular ecology · 2012Article
- Explaining the heritability of an ecologically significant trait in terms of individual quantitative trait loci.Biology letters · 2011Article
- Interactions among flower-size QTL of Mimulus guttatus are abundant but highly variable in nature.Genetics · 2011Article
- Rapid evolution caused by pollinator loss in Mimulus guttatus.Evolution; international journal of organic evolution · 2011Article
- Viability selection prior to trait expression is an essential component of natural selection.Proceedings. Biological sciences · 2010Article
- Mutation and the evolution of ageing: from biometrics to system genetics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Contribution of chromosomal polymorphisms to the G-matrix of Mimulus guttatus.The New phytologist · 2009Article
- Connecting QTLS to the g-matrix of evolutionary quantitative genetics.Evolution; international journal of organic evolution · 2009Article
- The genetic correlation between flower size and water use efficiency in monkeyflowers.Evolutionary ecology research · 2008Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
The rare-alleles model of quantitative variation posits that a common allele (the 'wild-type') and one or more rare alleles segregate at each locus affecting a quantitative trait; a scenario predicted by several distinct evolutionary hypotheses. Single locus arguments suggest that artificial selection should substantially increase the genetic variance (Vg) if the rare-alleles model is accurate. This paper tests the 'DeltaVg prediction' using a large artificial selection experiment on flower size of Mimulus guttatus. Vg for flower size does evolve, increasing with selection for larger flower while decreasing in the other direction. These data are consistent with a model in which flower size variation is caused by rare, partially dominant alleles. However, this explanation becomes increasingly tenuous when considered with other data (correlated responses to selection and the effects of inbreeding). A combination of modern (marker-based mapping) and classical (biometric) techniques will likely to be required to determine the distribution of allele frequencies at loci influencing quantitative traits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.