ReviewPathology oncology research : POR2007
Lewis x is highly expressed in normal tissues: a comparative immunohistochemical study and literature revision.
Review in Pathology oncology research : POR, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- Glycosylation in Cancer.Handbook of experimental pharmacology · 2025Review
- CD15 Is a Risk Predictor and a Novel Target in Clear Cell Renal Cell Carcinoma.Pathobiology : journal of immunopathology, molecular and cellular biology · 2024Article
- Characterization of N-glycome profile in mouse brain tissue regions by MALDI-TOF/MS.Analytical and bioanalytical chemistry · 2023Article
- SSEA-1 Correlates With the Invasive Phenotype in Breast Cancer.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2023Article
- Unique Tropism and Entry Mechanism of Mumps Virus.Viruses · 2021Review
- High-throughput surface marker screen on primary human breast tissues reveals further cellular heterogeneity.Breast cancer research : BCR · 2021Article
- Beyond Colonoscopy: Exploring New Cell Surface Biomarkers for Detection of Early, Heterogenous Colorectal Lesions.Frontiers in oncology · 2021Review
- Anti-Glycan Autoantibodies Induced byFrontiers in immunology · 2020Article
- Tumor recognition of peanut agglutinin-immobilized fluorescent nanospheres in biopsied human tissues.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2019Article
- Lewis x Antigen is Associated to Head and Neck Squamous Cell Carcinoma Survival.Pathology oncology research : POR · 2018Article
- Review
- Glycosyltransferases involved in the synthesis of MUC-associated metastasis-promoting selectin ligands.Glycobiology · 2015Article
- Anti-influenza neuraminidase inhibitor oseltamivir phosphate induces canine mammary cancer cell aggressiveness.PloS one · 2015Article
- Structural and functional characterization of NanU, a novel high-affinity sialic acid-inducible binding protein of oral and gut-dwelling Bacteroidetes species.The Biochemical journal · 2014Article
- Vibrio cholerae cytolysin recognizes the heptasaccharide core of complex N-glycans with nanomolar affinity.Journal of molecular biology · 2013Article
- Regulation of the metastatic cell phenotype by sialylated glycans.Cancer metastasis reviews · 2012Review
- Synthesis of 4" manipulated Lewis X trisaccharide analogues.Beilstein journal of organic chemistry · 2012Article
- Vaccine against MUC1 antigen expressed in inflammatory bowel disease and cancer lessens colonic inflammation and prevents progression to colitis-associated colon cancer.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- Convergent syntheses of Le analogues.Beilstein journal of organic chemistry · 2010Article
- Tumour-associated carbohydrate antigens in breast cancer.Breast cancer research : BCR · 2010Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An immunohistochemical analysis was employed to determine the expression of carbohydrate antigens associated to mucins in normal epithelia. Tissue samples were obtained as biopsies from normal breast (18), colon (35) and oral cavity mucosa (8). The following carbohydrate epitopes were studied: sialyl-Lewis x, Lewis x, Lewis y, Tn hapten, sialyl-Tn and Thomsen-Friedenreich antigen. Mucins were also studied employing antibodies against MUC1, MUC2, MUC4, MUC5AC, MUC6 and also normal colonic glycolipid. Statistical analysis was performed and Kendall correlations were obtained. Lewis x showed an apical pattern mainly at plasma membrane, although cytoplasmic staining was also found in most samples. TF, Tn and sTn haptens were detected in few specimens, while sLewis x was found in oral mucosa and breast tissue. Also, normal breast expressed MUC1 at a high percentage, whereas MUC4 was observed in a small number of samples. Colon specimens mainly expressed MUC2 and MUC1, while most oral mucosa samples expressed MUC4 and MUC1. A positive correlation between MUC1VNTR and TF epitope (r=0.396) was found in breast samples, while in colon specimens MUC2 and colonic glycolipid versus Lewis x were statistically significantly correlated (r=0.28 and r=0.29, respectively). As a conclusion, a defined carbohydrate epitope expression is not exclusive of normal tissue or a determined localization, and it is possible to assume that different glycoproteins and glycolipids may be carriers of carbohydrate antigens depending on the tissue localization considered.
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Registered trials
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