ArticleJournal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer2007
The IASLC Lung Cancer Staging Project: proposals for the revision of the N descriptors in the forthcoming seventh edition of the TNM classification for lung cancer.
Article in Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 2 of them syntheses that pooled it.
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Who cites it
153 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prognostic value of different N1 lymph node zones in pN1M0 non-small cell lung cancer: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- The role of EGFR-TKIs as adjuvant therapy in EGFR mutation-positive early-stage NSCLC: A meta-analysis.Thoracic cancer · 2021Pooled it
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- Prognostic significance of nodal subclassification and adjuvant therapy in surgically treated T1-4N1-2M0 non-small cell lung cancer: a single-center retrospective study.BMC pulmonary medicine · 2026Article
- Comparison Between Lymph Node Station- and Zone-Based Classification: An Extended Analysis With the Ninth Edition TNM Lymph Node Descriptors in Surgically Resected NSCLC.JTO clinical and research reports · 2026Article
- Ten-year review of endobronchial ultrasound-guided transbronchial needle aspiration for lymph node staging in lung cancer: Comparison with guidelines.JTCVS open · 2026Article
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- Survival effect of PET/CT-defined occult lymph node metastasis in the newly proposed ninth edition N descriptors: a multicentre study.European journal of nuclear medicine and molecular imaging · 2026Article
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- Impact of the number of involved lymph node zones on survival in stage IIIA-N2 lung adeno and squamous cell carcinoma.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Prognostic Value of Single Nodal Zone Metastasis in Non-Small-Cell Lung Cancer-A Multi-Institutional Study.Journal of clinical medicine · 2025Article
- Intraoperative support using mixed reality holograms for hilar and mediastinal lymph node dissection.Surgical endoscopy · 2025Article
- Differences in the Prognostic Impact between Single-Zone and Multi-Zone N2 Node Metastasis in Patients with Station-Based Multiple N2 Non-Small Cell Lung Cancer.Cancer research and treatment · 2025Article
- Unlocking the potential of immunotherapy for patients with resectable non-small cell lung cancer.Frontiers in oncology · 2025Review
- The TNM classification of lung cancer-a historic perspective.Journal of thoracic disease · 2024Review
- Number of involved nodal stations predicts survival in small cell lung cancer.BMC pulmonary medicine · 2024Article
- What Is the Accuracy of Clinical Staging for Stage III-Single-station N2 NSCLC? A Multi-Centre UK Study.JTO clinical and research reports · 2024Article
- Is the burden of metastatic lymph node stations a prognostic factor in patients with resected lung cancer?Journal of cardiothoracic surgery · 2024Article
- The International Association for the Study of Lung Cancer Staging Project for Lung Cancer: Proposals for the Revision of the N Descriptors in the Forthcoming Ninth Edition of the TNM Classification for Lung Cancer.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2024Article
93 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAccurate staging of lymph node involvement is a critical aspect of the initial management of nonmetastatic non-small cell lung cancer (NSCLC). We sought to determine whether the current N descriptors should be maintained or revised for the next edition of the international lung cancer staging system.
methodsA retrospective international lung cancer database was developed and analyzed. Anatomical location of lymph node involvement was defined by the Naruke (for Japanese data) and American Thoracic Society (for non-Japanese data) nodal maps. Survival was calculated by the Kaplan-Meier method, and prognostic groups were assessed by Cox regression analysis.
resultsCurrent N0 to N3 descriptors defined distinct prognostic groups for both clinical and pathologic staging. Exploratory analyses indicated that lymph node stations could be grouped together into six "zones": peripheral or hilar for N1, and upper or lower mediastinal, aortopulmonary, and subcarinal for N2 nodes. Among patients undergoing resection without induction therapy, there were three distinct prognostic groups: single-zone N1, multiple-zone N1 or single N2, and multiple-zone N2 disease. Nevertheless, there were insufficient data to determine whether the N descriptors should be subdivided (e.g., N1a, N1b, N2a, N2b).
conclusionsCurrent N descriptors should be maintained in the NSCLC staging system. Prospective studies are needed to validate amalgamating lymph node stations into zones and subdividing N descriptors.
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