Trial reportAntimicrobial agents and chemotherapy2007
Therapeutic effect of nisin Z on subclinical mastitis in lactating cows.
Trial report in Antimicrobial agents and chemotherapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed.
- Efficacy of vaccination and nisin Z treatments to eliminate intramammary Staphylococcus aureus infection in lactating cows.Journal of Zhejiang University. Science. BTrial
- In Vitro Assessment of Selected Postbiotic Substances Against Methicillin-Resistant and Methicillin-SusceptibleAnimals : an open access journal from MDPI · 2026Article
- The Microbial Composition of Bovine Colostrum as Influenced by Antibiotic Treatment.Antibiotics (Basel, Switzerland) · 2025Article
- Alternative approaches to antibiotics in the control of mastitis in dairy cows: a review.Veterinary research communications · 2025Review
- Editorial: Green Veterinary Pharmacology and Toxicology: a "One Health" Approach milestone.Frontiers in veterinary science · 2024Article
- Biosynthesis, classification, properties, and applications ofFrontiers in microbiology · 2024Review
- Nisin Z Potential for the Control of Diabetic Foot Infections Promoted byAntibiotics (Basel, Switzerland) · 2023Article
- Lactation performance and feed utilization of Rahmani ewes fed with either a newly produced bacteriocin-like substance or a commercial bacteriocin.Translational animal science · 2023Article
- Alternatives to antibiotics for treatment of mastitis in dairy cows.Frontiers in veterinary science · 2023Review
- Effects of nisin on the expression of virulence genes of methicillin-resistant/sensitiveIranian journal of microbiology · 2022Article
- Nisin Variants Generated by Protein Engineering and Their Properties.Bioengineering (Basel, Switzerland) · 2022Review
- Efficacy and mechanism of carvacrol with octanoic acid against mastitis causing multi-drug-resistant pathogens.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Advances in therapeutic and managemental approaches of bovine mastitis: a comprehensive review.The veterinary quarterly · 2021Review
- The Role ofMicroorganisms · 2021Review
- Bacteriocins from Lactic Acid Bacteria. A Powerful Alternative as Antimicrobials, Probiotics, and Immunomodulators in Veterinary Medicine.Animals : an open access journal from MDPI · 2021Review
- Bio-Engineered Nisin with Increased Anti-International journal of molecular sciences · 2021Article
- Anticancer and antimicrobial potential of enterocin 12a from Enterococcus faecium.BMC microbiology · 2021Article
- Bacteriocins: Potential for Human Health.Oxidative medicine and cellular longevity · 2021Review
- Efficacy of Phage- and Bacteriocin-Based Therapies in Combatting Nosocomial MRSA Infections.Frontiers in molecular biosciences · 2021Review
- Gram-positive bacteriocins: usage as antimicrobial agents in veterinary medicine.Veterinary research communications · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bovine subclinical mastitis is an inflammation of the mammary gland caused by bacterial intramammary infection, accounting for large economic losses. Treatment of subclinical mastitis is not suggested for lactating cows due to the risk of milk contamination. The objectives of this study were to evaluate an antimicrobial peptide, nisin, in the treatment of subclinical mastitis in lactating cows. A total of 90 lactating Holstein cows with subclinical mastitis were randomly divided into nisin-treated (n = 46) and control (n = 44) groups. In the nisin-treated group, cows received an intramammary infusion of nisin at a dose of 2,500,000 IU once daily for 3 days while the control cows received no treatment. Milk samples were collected from the affected mammary quarters before treatment and 1 and 2 weeks after treatment for analyses of bacteria, somatic cells, and N-acetyl-beta-D-glucosaminidase (NAGase). Results indicated that nisin therapy had bacteriological cure rates of 90.1% for Streptococcus agalactiae (10 of 11), 50% for Staphylococcus aureus (7 of 14), 58.8% for coagulase-negative staphylococci (7 of 17), and 65.2% for all cases (30 of 46). Meanwhile, only 15.9% (7 of 44) of untreated cows spontaneously recovered. NAGase activity in milk samples and the number of mammary quarters with a milk somatic cell count of > or =500,000/ml were significantly decreased after nisin treatment while no significant changes took place in the control group. Because of its therapeutic effects on bovine subclinical mastitis, as well as its safety in humans, nisin deserves further study to clarify its effects on mastitis caused by different pathogens.
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