ArticleBMC neuroscience2007
Transcranial magnetic stimulation for the treatment of tinnitus: effects on cortical excitability.
Article in BMC neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Modulated Alpha Power as a Predictor of Tinnitus Alleviation.The journal of international advanced otology · 2024Trial
- Medium-term results of combined treatment with transcranial magnetic stimulation and antidepressant drug for chronic tinnitus.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2015Trial
- Changes in motor cortex excitability associated with temporal repetitive transcranial magnetic stimulation in tinnitus: hints for cross-modal plasticity?BMC neuroscience · 2014Trial
- Low-frequency repetitive transcranial magnetic stimulation to the temporoparietal junction for tinnitus: four-week stimulation trial.JAMA otolaryngology-- head & neck surgery · 2013Trial
- Low-frequency repetitive transcranial magnetic stimulation to the temporoparietal junction for tinnitus.Archives of otolaryngology--head & neck surgery · 2011Trial
- Does a single session of theta-burst transcranial magnetic stimulation of inferior temporal cortex affect tinnitus perception?BMC neuroscience · 2009Trial
- Design of a placebo-controlled, randomized study of the efficacy of repetitive transcranial magnetic stimulation for the treatment of chronic tinnitus.BMC psychiatry · 2008Trial
- Prolonged P3 latency predicts clinical response to repetitive transcranial magnetic stimulation in tinnitus.Clinical neurophysiology practice · 2026Article
- Video-evoked neuromarkers of visual function in age-related macular degeneration.Frontiers in human neuroscience · 2025Article
- The alterations of repetitive transcranial magnetic stimulation on the energy landscape of resting-state networks differ across the human cortex.Human brain mapping · 2024Article
- Assessment of the Effectiveness of Transcranial Magnetic Stimulation in Subjective Tinnitus.International archives of otorhinolaryngology · 2021Article
- Homeostatic activity regulation as a mechanism underlying the effect of brain stimulation.Bioelectronic medicine · 2019Review
- A systematic review of non-motor rTMS induced motor cortex plasticity.Frontiers in human neuroscience · 2015Review
- Effects of individual alpha rTMS applied to the auditory cortex and its implications for the treatment of chronic tinnitus.Human brain mapping · 2014Article
- State- and trait-related alterations of motor cortex excitability in tinnitus patients.PloS one · 2014Article
- Targeting inhibitory neurotransmission in tinnitus.Brain research · 2012Review
- Predictors for rTMS response in chronic tinnitus.Frontiers in systems neuroscience · 2012Article
- Brain stimulation: new vistas for the exploration and treatment of tinnitus.CNS neuroscience & therapeutics · 2011Review
- Auditory cortex electrical stimulation suppresses tinnitus in rats.Journal of the Association for Research in Otolaryngology : JARO · 2011Article
- Transcranial magnetic simulation in the treatment of migraine.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2010Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow frequency repetitive transcranial magnetic stimulation (rTMS) has been proposed as an innovative treatment for chronic tinnitus. The aim of the present study was to elucidate the underlying mechanism and to evaluate the relationship between clinical outcome and changes in cortical excitability. We investigated ten patients with chronic tinnitus who participated in a sham-controlled crossover treatment trial. Magnetic-resonance-imaging and positron-emission-tomography guided 1 Hz rTMS were performed over the auditory cortex on 5 consecutive days. Active and sham treatments were separated by one week. Parameters of cortical excitability (motor thresholds, intracortical inhibition, intracortical facilitation, cortical silent period) were measured serially before and after rTMS treatment by using single- and paired-pulse transcranial magnetic stimulation. Clinical improvement was assessed with a standardized tinnitus-questionnaire.
resultsWe noted a significant interaction between treatment response and changes in motor cortex excitability during active rTMS. Specifically, clinical improvement was associated with an increase in intracortical inhibition, intracortical facilitation and a prolongation of the cortical silent period. These results indicate that intraindividual changes in cortical excitability may serve as a correlate of response to rTMS treatment.
conclusionThe observed alterations of cortical excitability suggest that low frequency rTMS may evoke long-term-depression like effects resulting in an improvement of subcortical inhibitory function.
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