ArticleIntensive care medicine2007
RIFLE classification can predict short-term prognosis in critically ill cirrhotic patients.
Article in Intensive care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- KASL clinical practice guidelines for liver cirrhosis: Ascites and related complications.Clinical and molecular hepatology · 2018Guideline
- Hepatorenal syndrome: the 8th International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group.Critical care (London, England) · 2012Pooled it
- The effect of diabetes on mortality in critically ill patients: a systematic review and meta-analysis.Critical care (London, England) · 2011Pooled it
- LC-Pred: A Transformer-Based Interactive Interface for Liver Cirrhosis Prediction.International journal of hepatology · 2026Article
- Acute kidney injury in chronic liver disease: Causes and prevalence in a cross-sectional study.Bioinformation · 2025Article
- Current knowledge about biomarkers of acute kidney injury in liver cirrhosis.Clinical and molecular hepatology · 2022Review
- Does Artificial Intelligence Make Clinical Decision Better? A Review of Artificial Intelligence and Machine Learning in Acute Kidney Injury Prediction.Healthcare (Basel, Switzerland) · 2021Review
- Acute kidney injury and hepatorenal syndrome in cirrhosis.World journal of gastroenterology · 2021Review
- Development and validation of a risk stratification model for predicting the mortality of acute kidney injury in critical care patients.Annals of translational medicine · 2021Article
- Renal replacement therapy: a practical update.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2019Review
- Acute Kidney Injury in Severe Trauma Patients; a Record-Based Retrospective Study.Advanced journal of emergency medicine · 2019Article
- "Normal" Creatinine Levels Predict Persistent Kidney Injury and Waitlist Mortality in Outpatients With Cirrhosis.Hepatology (Baltimore, Md.) · 2018Article
- Article
- Prognosis of cirrhotic patients admitted to intensive care unit: a meta-analysis.Annals of intensive care · 2017Article
- Acute Kidney Injury in Cirrhosis: Baseline Serum Creatinine Predicts Patient Outcomes.The American journal of gastroenterology · 2017Article
- Acute Kidney Injury Classification for Critically Ill Cirrhotic Patients: A Comparison of the KDIGO, AKIN, and RIFLE Classifications.Scientific reports · 2016Article
- Overview on acute-on-chronic liver failure.Frontiers of medicine · 2016Review
- The evolving concept of acute kidney injury in patients with cirrhosis.Nature reviews. Gastroenterology & hepatology · 2015Review
- Urinary Biomarkers Improve the Diagnosis of Intrinsic Acute Kidney Injury in Coronary Care Units.Medicine · 2015Observational
- Renal failure in cirrhosis: Emerging concepts.World journal of hepatology · 2015Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEnd-stage liver disease is frequently complicated by renal function disturbances. Cirrhotic patients with renal failure admitted to intensive care units (ICUs) have high mortality rates. This study analyzed the outcomes of critically ill cirrhotic patients and identified the association between prognosis and RIFLE (risk of renal failure, injury to kidney, failure of kidney function, loss of kidney function, and end-stage renal failure) classification, in comparison with other five scoring systems.
designProspective, clinical study.
settingTen-bed specialized hepatogastroenterology ICU in a university hospital in Taiwan. PATIENTS AND
participantsOne hundred and thirty-four cirrhotic patients consecutively admitted to ICU during a 1.5-year period.
interventionsThirty-two demographic, clinical and laboratory variables were analyzed as predictors of survival. MEASUREMENTS AND MAIN
resultsOverall hospital mortality was 65.7%. There was a progressive and significant increase (chi2 for trend: p<0.001) in mortality based on RIFLE classification severity. Multiple logistic regression analysis indicated that RIFLE classification and Sequential Organ Failure Assessment (SOFA) score on the first day of ICU admission were independent risk factors for hospital mortality. By using the areas under the receiver operating characteristic curve (AUROC), the RIFLE category and SOFA both indicated a good discriminative power (AUROC 0.837+/-0.036 and 0.917+/-0.025; p<0.001). Cumulative survival rates at 6-month follow-up differed significantly (p<0.05) for non-ARF vs. RIFLE-R, RIFLE-I, and RIFLE-F.
conclusionBoth SOFA and RIFLE category showed high discriminative power in predicting hospital mortality in critically ill patients with cirrhosis. The RIFLE classification is a simple and easily applied evaluative tool with good prognostic abilities.
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