ArticleAnnals of biomedical engineering2007
Anisotropic diffusive transport in annulus fibrosus: experimental determination of the diffusion tensor by FRAP technique.
Article in Annals of biomedical engineering, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Human mesenchymal stem/stromal cell-derived extracellular vesicle transport in meniscus fibrocartilage.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Effect of cigarette smoke exposure and cessation on regional diffusion properties in rat intervertebral discs.JOR spine · 2024Article
- Assessing the role of surface layer and molecular probe size in diffusion within meniscus tissue.PloS one · 2024Article
- Strain-Dependent Diffusivity of Small and Large Molecules in Meniscus.Journal of biomechanical engineering · 2022Article
- Review
- A noninvasive fluorescence imaging-based platform measures 3D anisotropic extracellular diffusion.Nature communications · 2021Article
- EFFECTS OF SOLUTE SIZE AND TISSUE COMPOSITION ON MOLECULAR AND MACROMOLECULAR DIFFUSIVITY IN HUMAN KNEE CARTILAGE.Osteoarthritis and cartilage open · 2020Article
- Molecular and macromolecular diffusion in human meniscus: relationships with tissue structure and composition.Osteoarthritis and cartilage · 2020Article
- Article
- Diffusion of antibiotics in intervertebral disc.Journal of biomechanics · 2018Article
- Review
- Measurement of three-dimensional anisotropic diffusion by multiphoton fluorescence recovery after photobleaching.Annals of biomedical engineering · 2014Article
- Effect of cartilage endplate on cell based disc regeneration: a finite element analysis.Molecular & cellular biomechanics : MCB · 2013Article
- Relationship between anisotropic diffusion properties and tissue morphology in porcine TMJ disc.Osteoarthritis and cartilage · 2013Article
- Simultaneous measurement of anisotropic solute diffusivity and binding reaction rates in biological tissues by FRAP.Annals of biomedical engineering · 2011Article
- Anisotropic solute diffusion tensor in porcine TMJ discs measured by FRAP with spatial Fourier analysis.Annals of biomedical engineering · 2010Article
- Relationship between solute transport properties and tissue morphology in human annulus fibrosus.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2009Article
- Strain-dependent oxygen diffusivity in bovine annulus fibrosus.Journal of biomechanical engineering · 2009Article
- Effect of mechanical loading on electrical conductivity in human intervertebral disk.Journal of biomechanical engineering · 2009Article
- Characterization of anisotropic diffusion tensor of solute in tissue by video-FRAP imaging technique.Annals of biomedical engineering · 2009Article
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2 authors.
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Abstract
The annulus fibrosus (AF) of the intervertebral disc (IVD) exhibits a fiber-organized structure which is responsible for anisotropic and inhomogeneous mechanical and transport properties. Due to its particular morphology, nutrient transport within AF is regulated by complex transport kinetics. This work investigates the diffusive transport of a small solute in the posterior and anterior regions of AF since diffusion is the major transport mechanism for low molecular weight nutrients (e.g., oxygen and glucose) in IVD. Diffusion coefficient (D) of fluorescein (332 Da) in bovine coccygeal AF was measured in the three major (axial, circumferential, and radial) directions of the IVD by means of fluorescence recovery after photobleaching (FRAP) technique. It was found that the diffusion coefficient was anisotropic and inhomogeneous. In both anterior and posterior regions, the diffusion coefficient in the radial direction was found to be the lowest. Circumferential and axial diffusion coefficients were not significantly different in both posterior and anterior regions and their values were about 130% and 150% the value of the radial diffusion coefficient, respectively. The values of diffusion coefficients in the anterior region were in general higher than those of corresponding diffusion coefficients in the posterior region. This study represents the first quantitative analysis of anisotropic diffusion transport in AF by means of FRAP technique and provides additional knowledge on understanding the pathways of nutritional supply into IVD.
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