ReviewNeurochemical research2008
Neurochemical consequences of dysphoric state during amphetamine withdrawal in animal models: a review.
Review in Neurochemical research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Locomotion changes in methamphetamine and amphetamine withdrawal: a systematic review.Frontiers in pharmacology · 2024Pooled it
- Methamphetamine Use During the First or Second Half of Pregnancy Worsens Cardiac Ischemic Injury in Adult Female Offspring.Physiological research · 2022Article
- Amphetamine exposure alters behaviors, and neuronal and neurochemical activation in the brain of female prairie voles.Neuroscience · 2022Article
- Diazepam reverses increased anxiety-like behavior, social behavior deficit, and dopamine dysregulation following withdrawal from acute amphetamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Effect of three different regimens of repeated methamphetamine on rats' cognitive performance.Cognitive processing · 2018Article
- Molecular, Behavioral, and Physiological Consequences of Methamphetamine Neurotoxicity: Implications for Treatment.The Journal of pharmacology and experimental therapeutics · 2017Review
- Role of Prefrontal Serotonergic and Dopaminergic Systems in Encounter-Induced Hyperactivity in Methamphetamine-Sensitized Mice.The international journal of neuropsychopharmacology · 2017Article
- Timing of amphetamine exposure in relation to puberty onset determines its effects on anhedonia, exploratory behavior, and dopamine DNeuroscience · 2016Article
- Reductions in frontocortical cytokine levels are associated with long-lasting alterations in reward valuation after methamphetamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Predicting abuse potential of stimulants and other dopaminergic drugs: overview and recommendations.Neuropharmacology · 2014Review
- Wake-promoting pharmacotherapy for psychiatric disorders.Current psychiatry reports · 2014Review
- A stress steroid triggers anxiety via increased expression of α4βδ GABAA receptors in methamphetamine dependence.Neuroscience · 2013Article
- Chronic pre-exposure to methamphetamine following 31 days of withdrawal impairs sexual performance but not sexual conditioning in male Japanese quail.Behavioural processes · 2012Article
- Inter-individual diversity and intra-individual stability of amphetamine-induced sensitization of frequency-modulated 50-kHz vocalization in Sprague-Dawley rats.Psychopharmacology · 2012Article
- A single administration of methamphetamine to mice early in the light period decreases running wheel activity observed during the dark period.Brain research · 2012Article
- The diagnostic dilemma of pathological appearance and performance enhancing drug use.Drug and alcohol dependence · 2011Review
- The effects of dose and repeated administration on the longer-term hypophagia produced by amphetamine in rats.Pharmacology, biochemistry, and behavior · 2010Article
- Withdrawal from chronic amphetamine produces persistent anxiety-like behavior but temporally-limited reductions in monoamines and neurogenesis in the adult rat dentate gyrus.Neuropharmacology · 2010Article
- Withdrawal from fixed-dose injection of methamphetamine decreases cerebral levels of 3-methoxy-4-hydroxyphenylglycol and induces the expression of anxiety-related behavior in mice.Neurochemical research · 2010Article
- Alterations in the levels of heterotrimeric G protein subunits induced by psychostimulants, opiates, barbiturates, and ethanol: Implications for drug dependence, tolerance, and withdrawal.Synapse (New York, N.Y.) · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic abuse of amphetamines, such as d-amphetamine (AMPH) and d-methamphetamine, results in psychological dependence, a condition in which the drug produces a feeling of satisfaction and a drive that requires periodic or continuous administration of the drug to produce overwhelming pleasure or to avoid discomfort such as dysphoria. The dysphoric state of AMPH withdrawal has been recognized as depressive syndromes, such as anhedonia, depression, anxiety, and social inhibition, in early drug abstinence. Medication for treatment of the dysphoric state is important for AMPH abusers to avoid impulsive self-injurious behavior or acts that are committed with unconscious or uncontrolled suicidal ideation. However, successful treatments for AMPH withdrawal remain elusive, since the exact molecular basis of the expression of dysphoria has not been fully elucidated. This review focuses on the molecular aspects of AMPH withdrawal as indexed by neurochemical parameters under a variety of injection regimens (for example, levels of brain monoamines and their metabolites, and gamma-aminobutyric acid, expression of genes and proteins involved in neuronal activity, and monoamine metabolism and availability) in rodent models which exhibit significant phenotypic features relevant to the syndromes of AMPH withdrawal in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.