ReviewLangenbeck's archives of surgery2007
Immune response of severely injured patients--influence of surgical intervention and therapeutic impact.
Review in Langenbeck's archives of surgery, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Severe Traumatic Injury Induces Phenotypic and Functional Changes of Neutrophils and Monocytes.Journal of clinical medicine · 2021Article
- BMP-2 delivery strategy modulates local bone regeneration and systemic immune responses to complex extremity trauma.Biomaterials science · 2021Article
- Early systemic immune biomarkers predict bone regeneration after trauma.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Circulating Extracellular Vesicles and Their miR "Barcode" Differentiate Alcohol Drinkers With Liver Injury and Those Without Liver Injury in Severe Trauma Patients.Frontiers in medicine · 2019Article
- An overview of cytokines and heat shock response in polytraumatized patients.Cell stress & chaperones · 2018Review
- The Effects ofJournal of tropical medicine · 2018Article
- Hepatocytes express the antimicrobial peptide HBD-2 after multiple trauma: an experimental study in human and mice.BMC musculoskeletal disorders · 2017Article
- Predictive value of cytokines for developing complications after polytrauma.World journal of critical care medicine · 2016Article
- Risk factors for sepsis in Korean trauma patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2016Article
- HLA-DR expression on monocytes is decreased in polytraumatized patients.European journal of medical research · 2015Article
- [Pathophysiology of multiple trauma : intensive care medicine and timing of treatment].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2013Review
- Comparison of the neutrophil proteome in trauma patients and normal controls.Protein and peptide letters · 2012Article
- Monocyte deactivation correlates with injury severity score, but not with heme oxygenase-1 levels in trauma patients.The Journal of surgical research · 2012Article
- Pseudofracture: an acute peripheral tissue trauma model.Journal of visualized experiments : JoVE · 2011Article
- Influence of small intestinal serosal defect closure on leakage rate and adhesion formation: a pilot study using rabbit models.Langenbeck's archives of surgery · 2011Article
- ATLS(R) and damage control in spine trauma.World journal of emergency surgery : WJES · 2009Article
- Polytrauma--pathophysiology and management principles.Langenbeck's archives of surgery · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background[corrected] Severe injury leads to a severe deterioration of the patients' immune response. The changes of the immune response after severe injury include a broad range of immune functions and may result in a status of immunosuppression, which could favor infectious complications. Therefore, immunostimulating therapies have been introduced in the therapy for severely injured patients in clinical and experimental settings.
objectivesThe article summarizes actual immunomodulating approaches in the treatment of trauma patients and therapeutic strategies avoiding additional immune deteriorations.
resultsExamples for an immunostimulating approach in trauma patients are interferon gamma and the granulocyte macrophage-colony-stimulating factor (GM-CSF), which are summarized in this review in detail. However, the effect of such an interference in the patients' immune response with all its different cellular targets is not yet clearly understood, and most studies focus on the reaction of circulating monocytes. In addition, further immunomodulating strategies, including nutritional support, are addressed. However, clinically established therapeutic immunomodulating strategies in trauma care so far do not exist. The impact of the accidental and also an additional surgical trauma on the immune response has been clearly demonstrated. Therefore, the idea of a "damage control orthopedic surgery" (DCOS) is not only necessary to prevent further deterioration of the homeostasis of, e.g., the coagulating system, but is also desirable in terms of minimizing the burden on the immune system. In addition, also the timing of secondary surgical treatment in trauma patient care should include an evaluation of the immune response, although the most reliable markers still need to be identified.
conclusionImmunomodulating therapies in trauma patients exist on an experimental level with inconsistent results. The general management of trauma patients includes strategies that have been developed also on the basis of immunological considerations.
Indexed as
Identifiers
17605036What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.