ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2007
Changes in aqueous humour following single or repeated UVB irradiation of rabbit cornea.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Neuropsin, TRPV4 and intracellular calcium mediate intrinsic photosensitivity in corneal epithelial cells.The ocular surface · 2025Article
- A class I (Senofilcon A) soft contact lens prevents UVB-induced ocular effects, including cataract, in the rabbit in vivo.Investigative ophthalmology & visual science · 2011Article
- The effect of single and repeated UVB radiation on rabbit lens.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAqueous humour is the main nutritive source for corneal and lenticular tissues, and knowledge of a possible cumulative effect of ultraviolet radiation (UVR) on its metabolic profile might be of great help in the assessment of cataract risks. By using high-resolution (1)H nuclear magnetic resonance (NMR) spectroscopy, it was possible to evaluate the effect of a single and repeated UVB radiation of the rabbit eye with the same overall dose on the aqueous humour.
methodsSamples of aqueous humour from twenty-four albino white rabbit eyes were examined for the effects of UVB exposure (312 nm). In the first group (UVB1), four animals were irradiated with a single dose 3.12 J/cm(2) (21 minutes) of UVB radiation. The animals in the second group (UVB2, n = 4) were irradiated three times for 7 minutes every 2nd day (dose of 1.04 J/cm(2); days 1, 3, 5) to give the same overall dose (3.12 J/cm(2)). The third group (n = 4) served as an untreated control group. (1)H NMR spectra of aqueous humour from all eyes were obtained. Special grouping patterns among the tissue samples and relative percentage changes in particular metabolite concentrations were evaluated using appropriate statistical methods (multivariate analysis, Independent sample t-test).
resultsSignificant alterations in the metabolic profile of aqueous humour from UVR-B exposed rabbit eyes and an apparent cumulative effect of repeated UVB irradiation were observed.
conclusionsApplication of a Carr-Purcell-Meiboom-Gill spin echo pulse sequence was found to have a great advantage for correct analysis of the results obtained with NMR spectroscopy of aqueous humour from eyes where increase of protein level due to an inflammatory process could not be excluded.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.