ArticleDiabetologia2007
Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes.
Article in Diabetologia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Liver sinusoidal endothelial cell defenestration in chronic heart failure is primarily dependent on cardiac diastolic dysfunction and is reversed by a sodium-glucose cotransporter 2 inhibitor but not by an angiotensin-converting enzyme inhibitor.Cardiovascular research · 2026Article
- Early and late phases of liver sinusoidal endothelial cell (LSEC) defenestration in mouse model of systemic inflammation.Cellular & molecular biology letters · 2024Article
- Article
- A standardized method for the analysis of liver sinusoidal endothelial cells and their fenestrations by scanning electron microscopy.Journal of visualized experiments : JoVE · 2015Article
- A Sieve-Raft Hypothesis for the regulation of endothelial fenestrations.Computational and structural biotechnology journal · 2013Review
- The baboon kidney transcriptome: analysis of transcript sequence, splice variants, and abundance.PloS one · 2013Article
- Loss of PDGF-B activity increases hepatic vascular permeability and enhances insulin sensitivity.American journal of physiology. Endocrinology and metabolism · 2011Article
- Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis.Cell metabolism · 2009Article
- Liver sinusoidal endothelial cells and acute non-oxidative hepatic injury induced by Pseudomonas aeruginosa pyocyanin.International journal of experimental pathology · 2008Article
- The response of fenestrations, actin, and caveolin-1 to vascular endothelial growth factor in SK Hep1 cells.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
Abstract
aims/hypothesisDiabetes mellitus is associated with extensive vascular pathology, yet little is known about its long-term effects on liver sinusoidal endothelial cells (LSECs). Potential diabetic changes in LSECs are important because of the role played by fenestrations in the LSECs in hepatic disposition of lipoproteins. MATERIALS AND
methodsSurgical liver biopsies for electron microscopy and immunohistochemistry were obtained from baboons with long-standing streptozotocin-induced, insulin-treated diabetes mellitus and compared with those from age-matched control animals.
resultsThere was an increase in the thickness of LSECs (170 +/- 17 vs 123 +/- 10 nm, p < 0.01). Fenestrations in LSECs, as determined by overall porosity, were markedly reduced (1.4 +/- 0.1% vs 2.6 +/- 0.2%, p < 0.01). Increased numbers of stellate cells were seen on electron microscopy, and this finding was corroborated by increased smooth muscle actin expression. Diabetes mellitus was also associated with increased endothelial production of von Willebrand factor and caveolin-1. CONCLUSIONS/
interpretationDiabetes mellitus in the non-human primate is associated with marked changes in LSECs, including a reduction in fenestrations. Such changes provide an additional and novel mechanism for impaired hepatic lipoprotein clearance and post-prandial hyperlipidaemia in diabetes mellitus.
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