ArticleAfrican health sciences2007
Effects of pirimiphos-methyl (an organophosphate insecticide) on the fertility of adult male rats.
Article in African health sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 69 citations in OpenAlex.
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- Effects of imidacloprid-contaminated feed exposure on spermatogenic cells and Leydig cells in testes of adult male rabbits (Saudi journal of biological sciences · 2023Article
- Mechanisms and histopathological impacts of acetamiprid and azoxystrobin in male rats.Environmental science and pollution research international · 2022Article
- Single injection of very mild dose botulinum toxin in the vastus lateralis improves testicular spermatogenesis and sperm motility in ageing experimental mice.Laboratory animal research · 2022Article
- Growth performance and reproductive function impairment of glyphosate-based herbicide in male guinea pig (Cavia porcellus).Veterinary medicine and science · 2021Article
- Sub-chronic dermal exposure to aircraft engine oils impacts the reproductive organ weights and alters hematological profiles of Sprague Dawley rats.Current research in toxicology · 2020Article
- Safety of Natural Insecticides: Toxic Effects on Experimental Animals.BioMed research international · 2018Review
- Antouka SuperHeliyon · 2017Article
- Dialkyl phosphate urinary metabolites and chromosomal abnormalities in human sperm.Environmental research · 2015Article
- The effects of pyridaben pesticide on the histomorphometric, hormonal alternations and reproductive functions of BALB/c mice.Iranian journal of basic medical sciences · 2013Article
- Emblica officinalis Garten fruits extract ameliorates reproductive injury and oxidative testicular toxicity induced by chlorpyrifos in male rats.SpringerPlus · 2013Article
- Widely used pesticides with previously unknown endocrine activity revealed as in vitro antiandrogens.Environmental health perspectives · 2011Article
- African Health Sciences. Editorial.African health sciences · 2007Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOrganophosphate insecticides represent one of the most widely used classes of pesticides with high potential for human exposure in both rural and residential environments.
objectiveIn the present study, we investigated the effects of pirimiphos-methyl (0, 2-diethylamino-6-methylpirimidin-4-yl O, O-dimethyl phosphorothioate), an organophosphothioate pesticide, on male rat reproductive performances.
methodsA total of 24 adult Wistar rats were divided into 4 groups of 6 animals each and orally treated with 0, 41.67, 62.5 or 125 mg/kg of pirimiphos-methyl for 90 days.
resultsResults from the study showed a significant increase (p<0.05) in feed consumption, body weight gain, relative testis and epidiydimis weights and intra-testicular cholesterol level in rats receiving the test substance at doses of 62.5 or 125 mg/kg whereas a significant decrease (p<0.05) in serum total protein, sperm density and motility, fertility and parturition indices and pups sex-ratio (M/F) was recorded in animals treated with 125 mg/Kg of pirimiphos methyl. Histological findings also indicated enlargement of interstitial space, inhibition of spermatogenesis, rarefaction of Leydig cells and oedema in testes compared to control animals.
conclusionIt could then be concluded that pirimiphos-methyl (62.5 and 125 mg/kg) is detrimental to the reproductive potentials of male rats.
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