ArticlePLoS genetics2007
The Genographic Project public participation mitochondrial DNA database.
Article in PLoS genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 169 citations in OpenAlex.
- Molecular oncology focus - is carcinogenesis a 'mitochondriopathy'?Journal of biomedical science · 2010Pooled it
- Pooled it
- Genetic ancestry of families of putative Inka descent.Molecular genetics and genomics : MGG · 2018Trial
- Mitochondrial variation in Taiwan Biobank reveals ancestry structure and trait associations.iScience · 2025Article
- mitoLEAF: mitochondrial DNA Lineage, Evolution, Annotation Framework.NAR genomics and bioinformatics · 2025Article
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- High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia.Genes · 2023Article
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- Ethical Guidance in Human Paleogenomics: New and Ongoing Perspectives.Annual review of genomics and human genetics · 2022Review
- Privacy, Data Sharing, and Data Security Policies of Women's mHealth Apps: Scoping Review and Content Analysis.JMIR mHealth and uHealth · 2022Article
- Y-DNA genetic evidence reveals several different ancient origins in the Brahmin population.Molecular genetics and genomics : MGG · 2021Article
- Evolving mtDNA populations within cells.Biochemical Society transactions · 2019Review
- Facial recognition from DNA using face-to-DNA classifiers.Nature communications · 2019Article
- Influence of Electron-Holes on DNA Sequence-Specific Mutation Rates.Genome biology and evolution · 2018Article
- The Geographic Origins of Ethnic Groups in the Indian Subcontinent: Exploring Ancient Footprints with Y-DNA Haplogroups.Frontiers in genetics · 2018Article
- Revising mtDNA haplotypes of the ancient Hungarian conquerors with next generation sequencing.PloS one · 2017Article
- The Genetic History of Peruvian Quechua-Lamistas and Chankas: Uniparental DNA Patterns among Autochthonous Amazonian and Andean Populations.Annals of human genetics · 2016Article
- The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease.Nature reviews. Genetics · 2015Review
- Two specific mutations are prevalent causes of recessive retinitis pigmentosa in North American patients of Jewish ancestry.Genetics in medicine : official journal of the American College of Medical Genetics · 2015Article
- Estimates of continental ancestry vary widely among individuals with the same mtDNA haplogroup.American journal of human genetics · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 7 institutions in 7 countries.
Funding
Abstract
The Genographic Project is studying the genetic signatures of ancient human migrations and creating an open-source research database. It allows members of the public to participate in a real-time anthropological genetics study by submitting personal samples for analysis and donating the genetic results to the database. We report our experience from the first 18 months of public participation in the Genographic Project, during which we have created the largest standardized human mitochondrial DNA (mtDNA) database ever collected, comprising 78,590 genotypes. Here, we detail our genotyping and quality assurance protocols including direct sequencing of the mtDNA HVS-I, genotyping of 22 coding-region SNPs, and a series of computational quality checks based on phylogenetic principles. This database is very informative with respect to mtDNA phylogeny and mutational dynamics, and its size allows us to develop a nearest neighbor-based methodology for mtDNA haplogroup prediction based on HVS-I motifs that is superior to classic rule-based approaches. We make available to the scientific community and general public two new resources: a periodically updated database comprising all data donated by participants, and the nearest neighbor haplogroup prediction tool.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.