ArticleBiophysical journal2007
Molecular motor-induced instabilities and cross linkers determine biopolymer organization.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 111 citations in OpenAlex.
- Three-dimensional robotic structures fabricated and powered entirely with proteins.Nature protocols · 2026Review
- Microscopic interactions control a structural transition in active mixtures of microtubules and molecular motors.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cytosolic actin isoforms form networks with different rheological properties that indicate specific biological function.Nature communications · 2023Article
- Systematic altering of semiflexible DNA-based polymer networksNanoscale · 2023Article
- 3D printed protein-based robotic structures actuated by molecular motor assemblies.Nature materials · 2022Article
- Constraint Release for Reptating Filaments in Semiflexible Networks Depends on Background Fluctuations.Polymers · 2022Article
- Large and stable: actin aster networks formedFrontiers in chemistry · 2022Article
- Tuning the Properties of Active Microtubule Networks by Depletion Forces.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- Effect of DNA Origami Nanostructures on hIAPP Aggregation.Nanomaterials (Basel, Switzerland) · 2020Article
- Time dependent stress relaxation and recovery in mechanically strained 3D microtissues.APL bioengineering · 2020Article
- Structural and mechanical remodeling of the cytoskeleton maintains tensional homeostasis in 3D microtissues under acute dynamic stretch.Scientific reports · 2020Article
- Myosin II Filament Dynamics in Actin Networks Revealed with Interferometric Scattering Microscopy.Biophysical journal · 2020Article
- The Actin Cytoskeleton as an Active Adaptive Material.Annual review of condensed matter physics · 2020Article
- Variations of Elastic Modulus and Cell Volume with Temperature for Cortical Neurons.Langmuir : the ACS journal of surfaces and colloids · 2019Article
- Prestressed cells are prone to cytoskeleton failures under localized shear strain: an experimental demonstration on muscle precursor cells.Scientific reports · 2018Article
- DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers.Journal of visualized experiments : JoVE · 2017Article
- Single Actin Bundle Rheology.Molecules (Basel, Switzerland) · 2017Article
- Semiflexible Biopolymers in Bundled Arrangements.Polymers · 2016Review
- MEDYAN: Mechanochemical Simulations of Contraction and Polarity Alignment in Actomyosin Networks.PLoS computational biology · 2016Article
- Actomyosin dynamics drive local membrane component organization in an in vitro active composite layer.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
All eukaryotic cells rely on the active self-organization of protein filaments to form a responsive intracellular cytoskeleton. The necessity of motility and reaction to stimuli additionally requires pathways that quickly and reversibly change cytoskeletal organization. While thermally driven order-disorder transitions are, from the viewpoint of physics, the most obvious method for controlling states of organization, the timescales necessary for effective cellular dynamics would require temperatures exceeding the physiologically viable temperature range. We report a mechanism whereby the molecular motor myosin II can cause near-instantaneous order-disorder transitions in reconstituted cytoskeletal actin solutions. When motor-induced filament sliding diminishes, the actin network structure rapidly and reversibly self-organizes into various assemblies. Addition of stable cross linkers was found to alter the architectures of ordered assemblies. These isothermal transitions between dynamic disorder and self-assembled ordered states illustrate that the interplay between passive crosslinking and molecular motor activity plays a substantial role in dynamic cellular organization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.