ArticleBiophysical journal2007
Sound-evoked radial strain in the hearing organ.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Inner hair cell stereocilia are embedded in the tectorial membrane.Nature communications · 2021Article
- Early Alterations of Endothelial Nitric Oxide Synthase Expression Patterns in the Guinea Pig Cochlea After Noise Exposure.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019Article
- Filtering of acoustic signals within the hearing organ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Tricellulin deficiency affects tight junction architecture and cochlear hair cells.The Journal of clinical investigation · 2013Article
- Instrumentation for studies of cochlear mechanics: from von Békésy forward.Hearing research · 2012Review
- Article
- Sound-induced length changes in outer hair cell stereocilia.Nature communications · 2012Article
- Biophysical mechanisms underlying outer hair cell loss associated with a shortened tectorial membrane.Journal of the Association for Research in Otolaryngology : JARO · 2011Article
- The endocochlear potential alters cochlear micromechanics.Biophysical journal · 2011Article
- A differentially amplified motion in the ear for near-threshold sound detection.Nature neuroscience · 2011Article
- Cadherins as targets for genetic diseases.Cold Spring Harbor perspectives in biology · 2010Review
- Vezatin, an integral membrane protein of adherens junctions, is required for the sound resilience of cochlear hair cells.EMBO molecular medicine · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hearing organ contains sensory hair cells, which convert sound-evoked vibration into action potentials in the auditory nerve. This process is greatly enhanced by molecular motors that reside within the outer hair cells, but the performance also depends on passive mechanical properties, such as the stiffness, mass, and friction of the structures within the organ of Corti. We used resampled confocal imaging to study the mechanical properties of the low-frequency regions of the cochlea. The data allowed us to estimate an important mechanical parameter, the radial strain, which was found to be 0.1% near the inner hair cells and 0.3% near the third row of outer hair cells during moderate-level sound stimulation. The strain was caused by differences in the motion trajectories of inner and outer hair cells. Motion perpendicular to the reticular lamina was greater at the outer hair cells, but inner hair cells showed greater radial vibration. These differences led to deformation of the reticular lamina, which connects the apex of the outer and inner hair cells. These results are important for understanding how the molecular motors of the outer hair cells can so profoundly affect auditory sensitivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.