ArticleAnnals of the rheumatic diseases2007
Microscopic measurement of inflammation in synovial tissue: inter-observer agreement for manual quantitative, semiquantitative and computerised digital image analysis.
Article in Annals of the rheumatic diseases, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Synovial tissue rank ligand expression and radiographic progression in rheumatoid arthritis: observations from a proof-of-concept randomized clinical trial of cytokine blockade.Rheumatology international · 2010Trial
- Immunological heterogeneity in rheumatoid arthritis: challenges in early-stage stratification, non-response to targeted therapy, and the restoration of immune tolerance.Frontiers in immunology · 2026Review
- Automated multi-scale computational pathotyping (AMSCP) of inflamed synovial tissue.Nature communications · 2024Article
- Impact of the biopsy forceps size on histological analysis and performances of the histological scoring systems.Scientific reports · 2022Article
- Computational pathology for musculoskeletal conditions using machine learning: advances, trends, and challenges.Arthritis research & therapy · 2022Review
- A convolutional neural network with transfer learning for automatic discrimination between low and high-grade synovitis: a pilot study.Internal and emergency medicine · 2021Article
- Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups.Arthritis research & therapy · 2018Article
- The relative composition of the inflammatory infiltrate as an additional tool for synovial tissue classification.PloS one · 2013Article
- Synovial tissue heterogeneity and peripheral blood biomarkers.Current rheumatology reports · 2011Review
- A role for the high-density lipoprotein receptor SR-B1 in synovial inflammation via serum amyloid-A.The American journal of pathology · 2010Article
- Utility of synovial biopsy.Arthritis research & therapy · 2009Review
- Computer-assisted validation of the synovitis score.Virchows Archiv : an international journal of pathology · 2008Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate inter-observer agreement for microscopic measurement of inflammation in synovial tissue using manual quantitative, semiquantitative and computerised digital image analysis.
methodsPaired serial sections of synovial tissue, obtained at arthroscopic biopsy of the knee from patients with rheumatoid arthritis (RA), were stained immunohistochemically for T lymphocyte (CD3) and macrophage (CD68) markers. Manual quantitative and semiquantitative scores for sub-lining layer CD3+ and CD68+ cell infiltration were independently derived in 6 international centres. Three centres derived scores using computerised digital image analysis. Inter-observer agreement was evaluated using Spearman's Rho and intraclass correlation coefficients (ICCs).
resultsPaired tissue sections from 12 patients were selected for evaluation. Satisfactory inter-observer agreement was demonstrated for all 3 methods of analysis. Using manual methods, ICCs for measurement of CD3+ and CD68+ cell infiltration were 0.73 and 0.73 for quantitative analysis and 0.83 and 0.78 for semiquantitative analysis, respectively. Corresponding ICCs of 0.79 and 0.58 were observed for the use of digital image analysis. All ICCs were significant at levels of p<0.0001. At each participating centre, use of computerised image analysis produced results that correlated strongly and significantly with those obtained using manual measurement.
conclusionStrong inter-observer agreement was demonstrated for microscopic measurement of synovial inflammation in RA using manual quantitative, semiquantitative and computerised digital methods of analysis. This further supports the development of these methods as outcome measures in RA.
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