ArticleDiagnostic pathology2007
Evaluation of oxidative stress in Insulin Dependent Diabetes Mellitus (IDDM) patients.
Article in Diagnostic pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 119 citations in OpenAlex.
- Effect of exercise therapy on lipid profile and oxidative stress indicators in patients with type 2 diabetes.BMC complementary and alternative medicine · 2008Trial
- Article
- Oxidant-modified amylin fibrils and aggregates alter the inflammatory profile of multiple myeloid cell types, but are non-toxic to islet β cells.Redox biology · 2023Article
- Metabolite Profiling, Antioxidant and Key Enzymes Linked to Hyperglycemia Inhibitory Activities ofMolecules (Basel, Switzerland) · 2022Article
- Association of Higher Advanced Oxidation Protein Products (AOPPs) Levels in Patients with Diabetic and Hypertensive Nephropathy.Medicina (Kaunas, Lithuania) · 2019Article
- Hyperglycemia and Carotenoid Intake Are Associated with Serum Carotenoids in Youth with Type 1 Diabetes.Journal of the Academy of Nutrition and Dietetics · 2019Article
- Plasma Protein Carbonylation in Haemodialysed Patients: Focus on Diabetes and Gender.Oxidative medicine and cellular longevity · 2018Article
- Black Seed Thymoquinone Improved Insulin Secretion, Hepatic Glycogen Storage, and Oxidative Stress in Streptozotocin-Induced Diabetic Male Wistar Rats.Oxidative medicine and cellular longevity · 2018Article
- Positive Correlation of Serum N-Acetyl-Disease markers · 2018Article
- Relationship between hyperglycemia, antioxidant capacity and some enzymatic and non-enzymatic antioxidants in African patients with type 2 diabetes.BMC research notes · 2017Article
- The Effect of Vitamin E on Oxidative Stress Indicated by Serum Malondialdehyde in Insulin-dependentThe open ophthalmology journal · 2017Article
- Article
- Status of Superoxide Dismutase in Transfusion Dependent Thalassaemia.North American journal of medical sciences · 2015Article
- Wogonin modulates hydroperoxide-induced apoptosis via PI3K/Akt pathway in retinal pigment epithelium cells.Diagnostic pathology · 2014Article
- Subclinical vascular endothelial dysfunctions and myocardial changes with type 1 diabetes mellitus in children and adolescents.Pediatric cardiology · 2014Article
- Study on total antioxidant status in relation to oxidative stress in type 2 diabetes mellitus.Journal of clinical and diagnostic research : JCDR · 2014Article
- Secondary analysis of publicly available data reveals superoxide and oxygen radical pathways are enriched for associations between type 2 diabetes and low-frequency variants.Annals of human genetics · 2013Article
- Protective and antidiabetic effects of extract from Nigella sativa on blood glucose concentrations against streptozotocin (STZ)-induced diabetic in rats: an experimental study with histopathological evaluation.Diagnostic pathology · 2013Article
- Haptoglobin2-2 phenotype is an additional risk factor of retinopathy in type 2 diabetes mellitus.Indian journal of human genetics · 2013Article
- Effect of yoga exercise therapy on oxidative stress indicators with end-stage renal disease on hemodialysis.International journal of yoga · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFree radical mediated oxidative stress is mainly involved in the pathogenesis of diabetic complications. Proteins and lipids are among the prime targets for oxidative stress. In the present study, we evaluated the oxidative stress in chronic IDDM patients by estimating the lipid peroxidation, protein oxidation, and antioxidants status. SUBJECTS AND
designA total of 35 (15 IDDM + 20 normal healthy) children were examined in the study and estimated the lipid peroxidation, protein oxidation, and antioxidants - vitamin A (beta-carotene, retinol), vitamin C, vitamin E and enzymatic antioxidants and nitric oxide.
resultsA statistically significant higher values of protein carbonyl groups and MDA as lipid peroxides were observed in diabetic patients with slight reduction in the synthesis of nitric oxide. It is interesting to note that there was a decrease in the antioxidant levels with corresponding increased protein and lipid oxidation. On PAGE under native conditions, we observed decreased levels of proteins - albumin, transferrin, ceruloplasmin and heptoglobulins and variable GC globulin fractions in IDDM compared to normal healthy controls.
conclusionHyperglycemia induces the overproduction of oxygen free radicals and consequently increases the protein oxidation and lipid oxidation. A significance difference in the mean plasma concentration of total antioxidant status was observed in IDDM patients. The findings of the present study suggest that diabetes in an altered metabolic state of oxidation-reduction and that it is convenient to give therapeutic interventions with antioxidants.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.