ReviewBritish journal of pharmacology2007
The potential of high-content high-throughput microscopy in drug discovery.
Review in British journal of pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed.
- Review
- Article
- Volumetric imaging of human mesenchymal stem cells (hMSCs) for non-destructive quantification of 3D cell culture growth.PloS one · 2023Article
- Generalising from conventional pipelines using deep learning in high-throughput screening workflows.Scientific reports · 2022Article
- Learning the rules of collective cell migration using deep attention networks.PLoS computational biology · 2022Article
- Monitoring cell endocytosis of liposomes by real-time electrical impedance spectroscopy.Analytical and bioanalytical chemistry · 2020Article
- Quantitative analysis of interactive behavior of mitochondria and lysosomes using structured illumination microscopy.Biomaterials · 2020Article
- Speckle-structured illumination for 3D phase and fluorescence computational microscopy.Biomedical optics express · 2019Article
- Computational structured illumination for high-content fluorescence and phase microscopy.Biomedical optics express · 2019Article
- Synthetic 10FN3-based mono- and bivalent inhibitors of MDM2/X function.Protein engineering, design & selection : PEDS · 2018Article
- Repurposing High-Throughput Image Assays Enables Biological Activity Prediction for Drug Discovery.Cell chemical biology · 2018Article
- High-speed Fourier ptychographic microscopy based on programmable annular illuminations.Scientific reports · 2018Article
- NMR-Fragment Based Virtual Screening: A Brief Overview.Molecules (Basel, Switzerland) · 2018Review
- Pluripotent Stem Cell-Derived Human Tissue: Platforms to Evaluate Drug Metabolism and Safety.The AAPS journal · 2017Review
- Large population cell characterization using quantitative phase cytometer.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2017Article
- New therapeutic approaches for Krabbe disease: The potential of pharmacological chaperones.Journal of neuroscience research · 2016Review
- Review
- Development of an image-based screening system for inhibitors of the plastidial MEP pathway and of protein geranylgeranylation.F1000Research · 2015Article
- Automated image-based assay for evaluation of HIV neutralization and cell-to-cell fusion inhibition.BMC infectious diseases · 2014Article
- Morphological Effects of Natural Products on Schizosaccharomyces pombe Measured by Imaging Flow Cytometry.Natural products and bioprospecting · 2014Article
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2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluorescence microscopy is a powerful method to study protein function in its natural habitat, the living cell. With the availability of the green fluorescent protein and its spectral variants, almost any gene of interest can be fluorescently labelled in living cells opening the possibility to study protein localization, dynamics and interactions. The emergence of automated cellular systems allows rapid visualization of large groups of cells and phenotypic analysis in a quantitative manner. Here, we discuss recent advances in high-content high-throughput microscopy and its potential application to several steps of the drug discovery process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.