ReviewBritish journal of pharmacology2007
Novel uses for anti-platelet agents as anti-inflammatory drugs.
Review in British journal of pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Clopidogrel treatment and the incidence and severity of community acquired pneumonia in a cohort study and meta-analysis of antiplatelet therapy in pneumonia and critical illness.Journal of thrombosis and thrombolysis · 2013Pooled it
- On the use of herbal medicines in management of inflammatory bowel diseases: a systematic review of animal and human studies.Digestive diseases and sciences · 2009Pooled it
- Factors associated with change in exacerbation frequency in COPD.Respiratory research · 2013Trial
- Non-fused Pyrimidine Derivatives as Potential Pharmacological Entities: A Review.Current topics in medicinal chemistry · 2025Review
- Platelets: a potential role in chronic respiratory diseases?European respiratory review : an official journal of the European Respiratory Society · 2021Review
- The blocking effect of the glycoprotein IIb/IIIa receptor in the mouse model of asthma.Clinical and molecular allergy : CMA · 2021Article
- Antiplatelet agents'-ticagrelol and eptifibatide-safety in experimental colitis in mice.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020Article
- Prognosis Value of Platelet Counts, Albumin and Neutrophil-Lymphocyte Ratio of Locoregional Recurrence in Patients with Operable Head and Neck Squamous Cell Carcinoma.Cancer management and research · 2020Article
- The Inhibition of P-Selectin Reduced Severe Acute Lung Injury in Immunocompromised Mice.Oxidative medicine and cellular longevity · 2020Article
- LPS-induced Lung Platelet Recruitment Occurs Independently from Neutrophils, PSGL-1, and P-Selectin.American journal of respiratory cell and molecular biology · 2019Article
- Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Article
- Phytotherapies in inflammatory bowel disease.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2019Review
- Article
- Platelets miRNA as a Prediction Marker of Thrombotic Episodes.Disease markers · 2016Review
- Platelets in inflammation: regulation of leukocyte activities and vascular repair.Frontiers in immunology · 2014Review
- Anti-inflammatory effects of tobramycin and a copper-tobramycin complex with superoxide dismutase-like activity.British journal of pharmacology · 2013Article
- Platelet activation, P-selectin, and eosinophil β1-integrin activation in asthma.American journal of respiratory and critical care medicine · 2012Article
- IL-17A increases ADP-induced platelet aggregation.Biochemical and biophysical research communications · 2011Article
- Airway platelet activation is associated with airway eosinophilic inflammation in asthma.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2010Article
- New steroidal glycosides isolated as CDL inhibitors of activated platelets.Molecules (Basel, Switzerland) · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An alteration in the character and function of platelets is manifested in patients with inflammatory diseases, and these alterations have been dissociated from the well-characterized involvement of platelets in thrombosis and haemostasis. Recent evidence reveals platelet activation is sometimes critical in the development of inflammation. The mechanisms by which platelets participate in inflammation are diverse, and offer numerous opportunities for future drug intervention. There is now acceptance that platelets act as innate inflammatory cells in immune responses, with roles as sentinel cells undergoing surveillance, responding to microbial invasion, orchestrating leukocyte recruitment, and migrating through tissue, causing damage and influencing repair processes in chronic disease. Some of these processes are targeted by drugs that are being developed to target platelet participation in atherosclerosis. The actions of platelets therefore influence the pathogenesis of diverse inflammatory diseases in various body compartments, encompassing parasitic and bacterial infection, allergic inflammation (especially asthma and rhinitis), and non-atopic inflammatory conditions, for example, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis (RA), inflammatory bowel disease (IBD) and atherosclerosis. This review will first discuss the evidence for platelet activation in these various inflammatory diseases, and secondly discuss the mechanisms by which this pathogenesis occurs and the various anti-platelet agents which have been developed to combat platelet activation in atherosclerosis and their potential future use for the treatment of other inflammatory diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.