ArticleBritish journal of pharmacology2007
Alpha1-adrenoceptors and ejaculatory function.
Article in British journal of pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- A meta-analysis of efficacy and safety of the new α1A-adrenoceptor-selective antagonist silodosin for treating lower urinary tract symptoms associated with BPH.Prostate cancer and prostatic diseases · 2013Pooled it
- Randomized crossover comparison of tamsulosin and alfuzosin in patients with urinary disturbances caused by benign prostatic hyperplasia.International urology and nephrology · 2011Trial
- Symptomatic and urodynamic responses in patients with reduced or no seminal emission during silodosin treatment for LUTS and BPH.Prostate cancer and prostatic diseases · 2011Trial
- Effects of Trazodone on Testicular Morphology, Sperm Parameters and Contractility of the Distal Cauda Epididymal Duct in Rats.Basic & clinical pharmacology & toxicology · 2026Article
- Alpha-Adrenoceptor Blockade as a Novel Pathway Toward Non-Hormonal Male Contraception: A Mechanistic and Clinical Evidence Review.Journal of clinical medicine · 2026Review
- Systemic alpha-1 adrenergic receptor inhibition reduces sperm damage in adult and aging spontaneously hypertensive rats.Scientific reports · 2024Article
- AlphaNaunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Emerging and investigational drugs for premature ejaculation.Translational andrology and urology · 2016Review
- Chronic prostatitis/chronic pelvic pain syndrome: a review of evaluation and therapy.Prostate cancer and prostatic diseases · 2016Review
- Regulation of nerve-evoked contractions of rabbit vas deferens by acetylcholine.Physiological reports · 2015Article
- Silodosin for the treatment of clinical benign prostatic hyperplasia: safety, efficacy, and patient acceptability.Research and reports in urology · 2014Review
- Benign prostatic hyperplasia: from bench to clinic.Korean journal of urology · 2012Article
- Sperm chromosomal aneuploidy and DNA integrity of infertile men with anejaculation.Journal of assisted reproduction and genetics · 2012Article
- Safety and efficacy of silodosin for the treatment of benign prostatic hyperplasia.Clinical interventions in aging · 2011Review
- Silodosin in the treatment of benign prostatic hyperplasia.Drug design, development and therapy · 2010Review
- Management of benign prostatic hyperplasia with silodosin.Open access journal of urology · 2009Review
- Subtypes of alpha1-adrenoceptors in BPH: future prospects for personalized medicine.Nature clinical practice. Urology · 2009Review
- Side Effects of alpha-Blocker Use: Retrograde Ejaculation.Reviews in urology · 2009Article
- Iloperidone-induced ejaculatory dysfunction: A case series.Indian journal of psychiatryArticle
Corrections and comments
- Comment on
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The abnormal ejaculation of semen is a typical but infrequent side effect of some alpha(1)-adrenoceptor antagonists, particularly those with selectivity for alpha(1A)-adrenoceptors such as silodosin or tamsulosin. Recent clinical studies suggest that this represents a relative anejaculation rather than a retrograde ejaculation. An elegant study in this issue of the journal using alpha(1A) single and alpha(1A/B/D) triple knock-out mice reports a similar phenomenon in rodents. Using a multi-disciplinary approach, the reduced ejaculation and related male infertility is shown to be caused by an impaired function of the vas deferens rather than by alterations in sperm formation, number or function. Similarities and differences between mouse and human data are discussed, particularly why a complete inhibition of all three alpha(1)-adrenoceptor subtypes has the strongest effects in mice whereas apparently only alpha(1A)-adrenoceptor-selective drugs impair ejaculatory function in humans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.