ArticleGenetics2007
Synthetic lethality of Drosophila in the absence of the MUS81 endonuclease and the DmBlm helicase is associated with elevated apoptosis.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 51 citations in OpenAlex.
- Divergence and conservation of the meiotic recombination machinery.Nature reviews. Genetics · 2024Review
- DNA polymerase theta suppresses mitotic crossing over.PLoS genetics · 2021Article
- History of DNA Helicases.Genes · 2020Review
- TheGenetics · 2019Article
- The topoisomerase 3α zinc-finger domain T1 of Arabidopsis thaliana is required for targeting the enzyme activity to Holliday junction-like DNA repair intermediates.PLoS genetics · 2018Article
- Substrate preference of Gen endonucleases highlights the importance of branched structures as DNA damage repair intermediates.Nucleic acids research · 2017Article
- Review
- Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression.Oncogene · 2015Article
- Drosophila FANCM helicase prevents spontaneous mitotic crossovers generated by the MUS81 and SLX1 nucleases.Genetics · 2014Article
- Holliday junction resolvases.Cold Spring Harbor perspectives in biology · 2014Review
- The dissolution of double Holliday junctions.Cold Spring Harbor perspectives in biology · 2014Review
- Temporal regulation of the Mus81-Mms4 endonuclease ensures cell survival under conditions of DNA damage.Nucleic acids research · 2013Article
- Synthetic lethality between gene defects affecting a single non-essential molecular pathway with reversible steps.PLoS computational biology · 2013Article
- The WRN and MUS81 proteins limit cell death and genome instability following oncogene activation.Oncogene · 2013Article
- Genetic analysis of mlh3 mutations reveals interactions between crossover promoting factors during meiosis in baker's yeast.G3 (Bethesda, Md.) · 2013Article
- Joint molecule resolution requires the redundant activities of MUS-81 and XPF-1 during Caenorhabditis elegans meiosis.PLoS genetics · 2013Article
- Meiotic development in Caenorhabditis elegans.Advances in experimental medicine and biology · 2013Review
- Cell cycle-dependent regulation of the nuclease activity of Mus81-Eme1/Mms4.Nucleic acids research · 2012Article
- Mus81-Mms4 functions as a single heterodimer to cleave nicked intermediates in recombinational DNA repair.Molecular and cellular biology · 2012Article
- BLM helicase ortholog Sgs1 is a central regulator of meiotic recombination intermediate metabolism.Molecular cell · 2012Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Mus81-Mms4 (Mus81-Eme1 in some species) is a heterodimeric DNA structure-specific endonuclease that has been implicated in meiotic recombination and processing of damaged replication forks in fungi. We generated and characterized mutations in Drosophila melanogaster mus81 and mms4. Unlike the case in fungi, we did not find any role for MUS81-MMS4 in meiotic crossing over. A possible role for this endonuclease in repairing double-strand breaks that arise during DNA replication is suggested by the finding that mus81 and mms4 mutants are hypersensitive to camptothecin; however, these mutants are not hypersensitive to other agents that generate lesions that slow or block DNA replication. In fungi, mus81, mms4, and eme1 mutations are synthetically lethal with mutations in genes encoding RecQ helicase homologs. Similarly, we found that mutations in Drosophila mus81 and mms4 are synthetically lethal with null mutations in mus309, which encodes the ortholog of the Bloom Syndrome helicase. Synthetic lethality is associated with high levels of apoptosis in proliferating tissues. Lethality and elevated apoptosis were partially suppressed by a mutation in spn-A, which encodes the ortholog of the strand invasion protein Rad51. These findings provide insights into the causes of synthetic lethality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.