ArticleGenetics2007
A clonal genetic screen for mutants causing defects in larval tracheal morphogenesis in Drosophila.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- TheProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- A Hippo-like Signaling Pathway Controls Tracheal Morphogenesis in Drosophila melanogaster.Developmental cell · 2018Article
- Dual function for Tango1 in secretion of bulky cargo and in ER-Golgi morphology.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Modeling congenital disease and inborn errors of development in Drosophila melanogaster.Disease models & mechanisms · 2016Review
- Cropped, Drosophila transcription factor AP-4, controls tracheal terminal branching and cell growth.BMC developmental biology · 2015Article
- Molecular mechanisms of de novo lumen formation.Nature reviews. Molecular cell biology · 2014Review
- Exocyst-mediated membrane trafficking is required for branch outgrowth in Drosophila tracheal terminal cells.Developmental biology · 2014Article
- Guidance of subcellular tubulogenesis by actin under the control of a synaptotagmin-like protein and Moesin.Nature communications · 2014Article
- Examination of Drosophila larval tracheal terminal cells by light microscopy.Journal of visualized experiments : JoVE · 2013Article
- Focal defects in single-celled tubes mutant for Cerebral cavernous malformation 3, GCKIII, or NSF2.Developmental cell · 2013Article
- Drosophila Zpr1 (Zinc finger protein 1) is required downstream of both EGFR and FGFR signaling in tracheal subcellular lumen formation.PloS one · 2012Article
- A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system.PLoS genetics · 2011Article
- Tube continued: morphogenesis of the Drosophila tracheal system.Current opinion in cell biology · 2010Review
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The initial establishment of the tracheal network in the Drosophila embryo is beginning to be understood in great detail, both in its genetic control cascades and in its cell biological events. By contrast, the vast expansion of the system during larval growth, with its extensive ramification of preexisting tracheal branches, has been analyzed less well. The mutant phenotypes of many genes involved in this process are probably not easy to reveal, as these genes may be required for other functions at earlier developmental stages. We therefore conducted a screen for defects in individual clonal homozygous mutant cells in the tracheal network of heterozygous larvae using the mosaic analysis with a repressible cell marker (MARCM) system to generate marked, recombinant mitotic clones. We describe the identification of a set of mutants with distinct phenotypic effects. In particular we found a range of defects in terminal cells, including failure in lumen formation and reduced or extensive branching. Other mutations affect cell growth, cell shape, and cell migration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.