ArticleBioconjugate chemistry
Development of a small peptide tag for covalent labeling of proteins.
Article in Bioconjugate chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Afterglow ice formed by phosphorescent luminophore-protein conjugates and complexes in aqueous solution at freezing temperature.Nature communications · 2025Article
- Peptide Tags for Site-Selective Nonenzymatic Covalent Modification of Proteins.Journal of peptide science : an official publication of the European Peptide Society · 2025Review
- Learning the structure-activity relationship (SAR) of the Wittig reaction from genetically-encoded substrates.Chemical science · 2021Article
- Efficient and wash-free labeling of membrane proteins using engineered Npu DnaE split-inteins.Protein science : a publication of the Protein Society · 2018Article
- Human Serum Albumin Domain I Fusion Protein for Antibody Conjugation.Bioconjugate chemistry · 2016Article
- Sequence-Specific 2-Cyanobenzothiazole Ligation.Journal of the American Chemical Society · 2016Article
- Identifying reactive peptides from phage-displayed libraries.Methods in molecular biology (Clifton, N.J.) · 2015Review
- Fast and sequence-specific palladium-mediated cross-coupling reaction identified from phage display.ACS chemical biology · 2014Article
- Hydrazide reactive peptide tags for site-specific protein labeling.Bioconjugate chemistry · 2011Article
- Labeling live cells by copper-catalyzed alkyne--azide click chemistry.Bioconjugate chemistry · 2010Article
- Synthesis and evaluation of a cyclic imine derivative conjugated to a fluorescent molecule for labeling of proteins.Bioorganic & medicinal chemistry letters · 2009Article
- Selection of phage-displayed peptides that bind to a particular ligand-bound antibody.Bioorganic & medicinal chemistry · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
A 21-mer peptide that can be used to covalently introduce synthetic molecules into proteins has been developed. Phage-displayed peptide libraries were subjected to reaction-based selection with 1,3-diketones. The peptide was further evolved by addition of a randomized region and reselection for improved binding. The resulting 21-mer peptide had a reactive amino group that formed an enaminone with 1,3-diketone and was used as a tag for labeling of maltose binding protein. Using this peptide tag and 1,3-diketone derivatives, a variety of molecules such as reporter probes and functionalities may be covalently introduced into proteins of interest.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.