ReviewRNA (New York, N.Y.)2007
RNA-based regulation of genes of tryptophan synthesis and degradation, in bacteria.
Review in RNA (New York, N.Y.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 139 citations in OpenAlex.
- Microbial shifts in early life: the pediatric gut microbiome and its role in health and disease.Gut microbes · 2026Review
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- Nucleotide dependency analysis of genomic language models detects functional elements.Nature genetics · 2025Article
- Solution structure, dynamics and tetrahedral assembly of Anti-TRAP, a homo-trimeric triskelion-shaped regulator of tryptophan biosynthesis inJournal of structural biology: X · 2024Article
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- The DNA damage response ofProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Multi-omics analysis of the gut microbiome and metabolites associated with the psychoneurological symptom cluster in children with cancer receiving chemotherapy.Journal of translational medicine · 2024Article
- Rho-dependent termination enables cellular pH homeostasis.Journal of bacteriology · 2024Article
- Age-dependent changes in the gut microbiota and serum metabolome correlate with renal function and human aging.Aging cell · 2023Article
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- Engineering Toehold-Mediated Switches for Native RNA Detection and Regulation in Bacteria.Journal of molecular biology · 2022Review
- Metabolic Pathways Associated With Psychoneurological Symptoms in Children With Cancer Receiving Chemotherapy.Biological research for nursing · 2022Article
- Bacterial Indole as a Multifunctional Regulator of Klebsiella oxytoca Complex Enterotoxicity.mBio · 2022Article
- Connecting gut microbiomes and short chain fatty acids with the serotonergic system and behavior inFrontiers in physiology · 2022Review
- Indole and p-cresol in feces of healthy subjects: Concentration, kinetics, and correlation with microbiome.Frontiers in molecular medicine · 2022Article
- Allosteric regulation of substrate channeling:Frontiers in molecular biosciences · 2022Review
- A novel strategy for D-psicose and lipase co-production using a co-culture system of engineered Bacillus subtilis and Escherichia coli and bioprocess analysis using metabolomics.Bioresources and bioprocessing · 2021Article
- Ribonuclease J-Mediated mRNA Turnover Modulates Cell Shape, Metabolism and Virulence inMicroorganisms · 2021Article
- Gut Microbiome Associated with the Psychoneurological Symptom Cluster in Patients with Head and Neck Cancers.Cancers · 2020Article
- Posttranscriptional Regulation ofJournal of bacteriology · 2020Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We are now aware that RNA-based regulatory mechanisms are commonly used to control gene expression in many organisms. These mechanisms offer the opportunity to exploit relatively short, unique RNA sequences, in altering transcription, translation, and/or mRNA stability, in response to the presence of a small or large signal molecule. The ability of an RNA segment to fold and form alternative hairpin secondary structures -- each dedicated to a different regulatory function -- permits selection of specific sequences that can affect transcription and/or translation. In the present paper I will focus on our current understanding of the RNA-based regulatory mechanisms used by Escherichia coli and Bacillus subtilis in controlling expression of the tryptophan biosynthetic operon. The regulatory mechanisms they use for this purpose differ, suggesting that these organisms, or their ancestors, adopted different strategies during their evolution. I will also describe the RNA-based mechanism used by E. coli in regulating expression of its operon responsible for tryptophan degradation, the tryptophanase operon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.