ArticleJournal of bacteriology2007
Regulation of pyr gene expression in Mycobacterium smegmatis by PyrR-dependent translational repression.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence.MicrobiologyOpen · 2026Review
- Unveiling the probiotic potential of the genus Geobacillus through comparative genomics and in silico analysis.Scientific reports · 2025Article
- Pyrimidine sufficiency is required for Sae two-component system signaling inJournal of bacteriology · 2025Article
- Improvement of the Genome Editing Tools Based on 5FC/5FU Counter Selection inMicroorganisms · 2023Article
- Pyrancoumarin derivative LP4C targeting of pyrimidineFrontiers in pharmacology · 2022Article
- Genetics of Lactococci.Microbiology spectrum · 2019Review
- Housecleaning of pyrimidine nucleotide pool coordinates metabolic adaptation of nongrowing Mycobacterium tuberculosis.Emerging microbes & infections · 2019Article
- Oxidation of dCTP contributes to antibiotic lethality in stationary-phase mycobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Regulation of the Expression of De Novo Pyrimidine Biosynthesis Genes in Corynebacterium glutamicum.Journal of bacteriology · 2015Article
- Discoveries in bacterial nucleotide metabolism.The Journal of biological chemistry · 2009Review
- Regulation of translation initiation by RNA binding proteins.Annual review of microbiology · 2009Review
- Expression, purification and preliminary X-ray diffraction studies of the transcriptional factor PyrR from Bacillus halodurans.Acta crystallographica. Section F, Structural biology and crystallization communications · 2008Article
- Regulation of pyrimidine biosynthetic gene expression in bacteria: repression without repressors.Microbiology and molecular biology reviews : MMBR · 2008Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Regulation of pyrimidine biosynthetic (pyr) genes by a transcription attenuation mechanism that is mediated by the PyrR mRNA-binding regulatory protein has been demonstrated for numerous gram-positive bacteria. Mycobacterial genomes specify pyrR genes and contain obvious PyrR-binding sequences in the initially transcribed regions of their pyr operons, but transcription antiterminator and attenuation terminator sequences are absent from their pyr 5' leader regions. This work demonstrates that repression of pyr operon expression in Mycobacterium smegmatis by exogenous uracil requires the pyrR gene and the pyr leader RNA sequence for binding of PyrR. Plasmids containing the M. smegmatis pyr promoter-leader region translationally fused to lacZ also displayed pyrR-dependent repression, but transcriptional fusions of the same sequences to a lacZ gene that retained the lacZ ribosome-binding site were not regulated by PyrR plus uracil. We propose that PyrR regulates pyr expression in M. smegmatis, other mycobacteria, and probably in numerous other bacteria by a translational repression mechanism in which nucleotide-regulated binding of PyrR occludes the first ribosome-binding site of the pyr operon.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.