ArticleBMC genetics2007
A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
Article in BMC genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
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- Genetic characterization of Macaca arctoides: A highlight of key genes and pathways.Primates; journal of primatology · 2023Article
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- Interdisciplinary Approach to Biological and Health Implications in Selected Professional Competences.Brain sciences · 2022Review
- Alzheimer's Disease-Related Genes Identified by Linking Spatial Patterns of Pathology and Gene Expression.Frontiers in neuroscience · 2022Article
- Association between genetic variants of the cholinergic system and postoperative delirium and cognitive dysfunction in elderly patients.BMC medical genomics · 2021Observational
- Glutathione S-transferase, catalase, and mitochondrial superoxide dismutase gene polymorphisms modulate redox potential in systemic lupus erythematosus patients from Manaus, Amazonas, Brazil.Clinical rheumatology · 2021Article
- Random forest-integrated analysis in AD and LATE brain transcriptome-wide data to identify disease-specific gene expression.PloS one · 2021Article
- PPAR and GST polymorphisms may predict changes in intellectual functioning in medulloblastoma survivors.Journal of neuro-oncology · 2019Article
- Multi-breed genome-wide association studies across countries for electronically recorded behavior traits in local dual-purpose cows.PloS one · 2019Article
- Human Lineage-Specific Transcriptional Regulation through GA-Binding Protein Transcription Factor Alpha (GABPa).Molecular biology and evolution · 2016Article
- Polymorphism of Nitric Oxide Synthase 1 Affects the Clinical Phenotypes of Ischemic Stroke in Korean Population.Annals of rehabilitation medicine · 2016Article
- Effect of Gene-Mercury Interactions on Mercury Toxicokinetics and Neurotoxicity.Current environmental health reports · 2015Review
- The genetic basis of quality of life in healthy Swedish women: a candidate gene approach.PloS one · 2015Article
- Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway.Experimental gerontology · 2014Article
- Oxidative stress and genetic markers of suboptimal antioxidant defense in the aging brain: a theoretical review.Reviews in the neurosciences · 2014Review
- Locus heterogeneity disease genes encode proteins with high interconnectivity in the human protein interaction network.Frontiers in genetics · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundNon-pathological cognitive ageing is a distressing condition affecting an increasing number of people in our 'ageing society'. Oxidative stress is hypothesised to have a major role in cellular ageing, including brain ageing.
resultsAssociations between cognitive ageing and 325 single nucleotide polymorphisms (SNPs), located in 109 genes implicated in oxidative stress and/or cognition, were examined in a unique cohort of relatively healthy older people, on whom we have cognitive ability scores at ages 11 and 79 years (LBC1921). SNPs showing a significant positive association were then genotyped in a second cohort for whom we have cognitive ability scores at the ages of 11 and 64 years (ABC1936). An intronic SNP in the APP gene (rs2830102) was significantly associated with cognitive ageing in both LBC1921 and a combined LBC1921/ABC1936 analysis (p < 0.01), but not in ABC1936 alone.
conclusionThis study suggests a possible role for APP in normal cognitive ageing, in addition to its role in Alzheimer's disease.
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