ArticleBMC genomics2007
Discovering multiple transcripts of human hepatocytes using massively parallel signature sequencing (MPSS).
Article in BMC genomics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Cucurbitacin IIa promotes the immunogenic cell death‑inducing effect of doxorubicin and modulates immune microenvironment in liver cancer.International journal of oncology · 2024Article
- Differential expression of microRNA between normally developed and underdeveloped female worms of Schistosoma japonicum.Veterinary research · 2020Article
- Improving Prediction of Self-interacting Proteins Using Stacked Sparse Auto-Encoder with PSSM profiles.International journal of biological sciences · 2018Article
- Novel expression profiles of microRNAs suggest that specific miRNAs regulate gene expression for the sexual maturation of female Schistosoma japonicum after pairing.Parasites & vectors · 2014Article
- Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- Profiles of small non-coding RNAs in Schistosoma japonicum during development.PLoS neglected tropical diseases · 2011Article
- Genome-wide identification of Schistosoma japonicum microRNAs using a deep-sequencing approach.PloS one · 2009Article
- Expression profiling of interindividual variability following xenobiotic exposures in primary human hepatocyte cultures.Toxicology and applied pharmacology · 2008Article
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Authors and funding
14 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe liver is the largest human internal organ--it is composed of multiple cell types and plays a vital role in fulfilling the body's metabolic needs and maintaining homeostasis. Of these cell types the hepatocytes, which account for three-quarters of the liver's volume, perform its main functions. To discover the molecular basis of hepatocyte function, we employed Massively Parallel Signature Sequencing (MPSS) to determine the transcriptomic profile of adult human hepatocytes obtained by laser capture microdissection (LCM).
results10,279 UniGene clusters, representing 7,475 known genes, were detected in human hepatocytes. In addition, 1,819 unique MPSS signatures matching the antisense strand of 1,605 non-redundant UniGene clusters (such as APOC1, APOC2, APOB and APOH) were highly expressed in hepatocytes.
conclusionApart from a large number of protein-coding genes, some of the antisense transcripts expressed in hepatocytes could play important roles in transcriptional interference via a cis-/trans-regulation mechanism. Our result provided a comprehensively transcriptomic atlas of human hepatocytes using MPSS technique, which could be served as an available resource for an in-depth understanding of human liver biology and diseases.
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