Synthesis of a universal 5-nitroindole ribonucleotide and incorporation into RNA by a viral RNA-dependent RNA polymerase.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

12 citing papers in PubMed.

1. Synthesis of 4-Cyanoindole Nucleosides, 4-Cyanoindole-2'-Deoxyribonucleoside-5'-Triphosphate (4CIN-TP), and Enzymatic Incorporation of 4CIN-TP into DNA.Current protocols in nucleic acid chemistry · 2020
   Article
2. Targeting the Viral Polymerase of Diarrhea-Causing Viruses as a Strategy to Develop a Single Broad-Spectrum Antiviral Therapy.Viruses · 2019
   Review
3. Structure(s), function(s), and inhibition of the RNA-dependent RNA polymerase of noroviruses.Virus research · 2017
   Review
4. Arenaviruses and lethal mutagenesis. Prospects for new ribavirin-based interventions.Viruses · 2012
   Review
5. Viral quasispecies evolution.Microbiology and molecular biology reviews : MMBR · 2012
   Review
6. Lethal mutagenesis: targeting the mutator phenotype in cancer.Seminars in cancer biology · 2010
   Review
7. A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape.PLoS pathogens · 2010
   Article
8. Potential benefits of sequential inhibitor-mutagen treatments of RNA virus infections.PLoS pathogens · 2009
   Article
9. Cationic nucleoside lipids based on a 3-nitropyrrole universal base for siRNA delivery.Bioconjugate chemistry · 2009
   Article
10. Therapeutically targeting RNA viruses via lethal mutagenesis.Future virology · 2008
    Article
11. One-pot synthesis of nucleoside 5'-triphosphates from nucleoside 5'-H-phosphonates.Organic letters · 2008
    Article
12. Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue.Journal of virology · 2007
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

6 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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